The simple synthesis of aminoribosyl uridines substituted by a 5′-methylene-urea is described. Their convergent synthesis entails the urea formation from numerous activated amides and an azidoribosyl uridine substituted on the 5′ place by an aminomethyl group. This widespread intermediate resulted from the diastereoselective glycosylation of a phthalimido uridine spinoff with a ribosyl fluoride as a ribosyl donor. The inhibition of the MraY transferase exercise by the synthetized 11 urea-containing inhibitors was evaluated and 10 compounds revealed MraY inhibition with IC50 starting from 1.9 μM to 16.7 μM. Their antibacterial exercise was additionally evaluated on a panel of Gram-positive and Gram-negative micro organism.
4 compounds exhibited a very good exercise in opposition to Gram-positive bacterial pathogens with MIC starting from eight to 32 μg mL-1, together with methicillin resistant Staphylococcus aureus (MRSA) and Enterococcus faecium. Curiously, one compound additionally revealed antibacterial exercise in opposition to Pseudomonas aeruginosa with MIC equal to 64 μg mL-1. Docking experiments predicted two modes of positioning of the lively compounds urea chain in numerous hydrophobic areas (HS2 and HS4) inside the MraY lively web site from Aquifex aeolicus. Nonetheless, molecular dynamics simulations confirmed that the urea chain adopts a binding mode much like that noticed in 5CKR structural mannequin and targets the hydrophobic space HS2.
Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically concerned in antimetastatic impact of melatonin in colorectal cancers
Within the present research, the underlying anti-metastatic mechanism of melatonin contained in some edible crops was explored in affiliation with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal most cancers cells. Right here, TMPRSS4 was extremely expressed in HCT15, however was weakly expressed in SW620 cells.
Melatonin exerted weak cytotoxicity, decreased invasion, adhesion, and migration, and attenuated the expression of TMPRSS4, cyclin E, pro-urokinase-type plasminogen activator (pro-uPA), p-signal transducer and activator of transcription 3 (p-STAT3), p-focal adhesion kinase (p-FAK), Snail and elevated the expression of E-cadherin, p27, pp38 and p-Jun N-terminal kinases (p-JNK) in HCT15 cells. Conversely, overexpression of TMPRSS4 lowered the flexibility of melatonin to activate E-cadherin and scale back Snail.
Moreover, even in SW620 cells transfected with TMPRSS4-overexpression plasmid, melatonin successfully suppressed invasion and migration together with decreased expression of Snail, cyclin A, cyclin E, pro-uPA and p-FAK and elevated expression of E-cadherin and p27. Total, these findings present proof that melatonin suppresses metastasis in colon most cancers cells by way of inhibition of TMPRSS4 mediated EMT.
POSTMEAL OPTOGENETIC INHIBITION OF DORSAL HIPPOCAMPAL PRINCIPAL NEURONS INCREASES FUTURE INTAKE IN A TIME-DEPENDENT MANNER
Analysis involving human members signifies that recollections of lately eaten meals restrict how a lot is eaten throughout subsequent consuming episodes; but, the mind areas that mediate the inhibitory results of ingestion-related reminiscence on future consumption are largely unknown. We hypothesize that dorsal hippocampal (dHC) neurons, that are essential for episodic recollections of private experiences, mediate the inhibitory results of ingestion-related reminiscence on future consumption. Our analysis program geared toward testing this speculation has been influenced largely by our mentor James McGaugh and his analysis on posttraining manipulations.
Within the current research, we used an activity-guided optogenetic strategy to check the prediction that if dHC glutamatergic neurons restrict future consumption by way of a course of that requires reminiscence consolidation, then inhibition ought to enhance subsequent consumption when given quickly after the tip of a meal however delayed inhibition should not have any impact.
Viral vectors containing CaMKIIα-eArchT3.0-eYFP and fiber optic probes had been positioned within the dHC of male Sprague-Dawley rats. In comparison with consumption on a day when no inhibition was given, postmeal inhibition of dHC glutamatergic neurons given for 10 min after the tip of a saccharin meal elevated the chance that rats would eat a second meal 90 min later and considerably elevated the quantity of saccharin resolution consumed throughout that subsequent meal when the neurons had been not inhibited.
Importantly, delayed inhibition given 80 min after the tip of the saccharin meal didn’t have an effect on subsequent consumption of saccharin. On condition that saccharin has minimal postingestive gastric penalties, these results aren’t seemingly because of the timing of interoceptive visceral cues generated by the meal. These knowledge present that dHC glutamatergic neural exercise is critical throughout the early postprandial interval for limiting future consumption and counsel that these neurons inhibit future consumption by consolidating the reminiscence of the previous meal.
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic steadiness
Dihydroorotate dehydrogenase (DHODH) is important for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been lengthy used to deal with autoimmune ailments and are in medical trials for most cancers and viral infections. Curiously, DHODH is positioned within the interior mitochondrial membrane and contributes to offer ubiquinol to the respiratory chain. Thus, DHODH supplies the hyperlink between nucleotide metabolism and mitochondrial perform.
 AssayMax ELISA Kit) Human Plasminogen Activator Inhibitor-1 (PAI-1) AssayMax ELISA Kit |
|
EP1100-1 |
AssayPro |
96 Well Plate |
EUR 500.4 |
) Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
|
1-CSB-EP021070RA |
Cusabio |
-
EUR 606.00
-
EUR 318.00
-
EUR 2192.40
-
EUR 919.20
-
EUR 1461.60
-
EUR 402.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in E.coli |
Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
|
1-CSB-YP021070RA |
Cusabio |
-
EUR 604.80
-
EUR 318.00
-
EUR 2198.40
-
EUR 915.60
-
EUR 1459.20
-
EUR 400.80
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in Yeast |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
 ELISA Kit) Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Mu-48T |
DL Develop |
48T |
EUR 522 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Mu-96T |
DL Develop |
96T |
EUR 673.2 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 536.4 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 741.6 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 514.8 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709.2 |
 HRP-Goat Anti-Mouse Secondary Antibody |
|
A12003 |
EpiGentek |
|
|
 Mouse plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
|
1-CSB-E07947m |
Cusabio |
-
EUR 1135.20
-
EUR 6938.40
-
EUR 3672.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Plasminogen activator inhibitor 2 type A Antibody |
|
20-abx109400 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody) Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Antibody |
|
20-abx142242 |
Abbexa |
-
EUR 444.00
-
EUR 727.20
-
EUR 376.80
|
|
|
|
) Rat Plasminogen activator inhibitor 1 (Serpine1) |
|
1-CSB-EP021081RA |
Cusabio |
-
EUR 606.00
-
EUR 318.00
-
EUR 2192.40
-
EUR 919.20
-
EUR 1461.60
-
EUR 402.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 1(Serpine1) expressed in E.coli |
) Human Plasminogen activator inhibitor 1 (SERPINE1) |
|
1-CSB-RP112394h |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),partial expressed in E.coli |
 anti-HGF |
|
YF-PA23875 |
Abfrontier |
50 ul |
EUR 400.8 |
|
Description: Mouse polyclonal to HGF |
anti-HGF |
|
YF-PA12302 |
Abfrontier |
100 ug |
EUR 483.6 |
|
Description: Rabbit polyclonal to HGF |
 Protein) Mouse Plasminogen Activator Inhibitor 1 (PAI1) Protein |
|
20-abx168332 |
Abbexa |
-
EUR 777.60
-
EUR 326.40
-
EUR 2331.60
-
EUR 910.80
-
EUR 560.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Human Plasminogen Activator Inhibitor-1 |
|
7-03571 |
CHI Scientific |
2µg |
Ask for price |
Human Plasminogen Activator Inhibitor-1 |
|
7-03572 |
CHI Scientific |
10µg |
Ask for price |
Human Plasminogen Activator Inhibitor-1 |
|
7-03573 |
CHI Scientific |
1mg |
Ask for price |
) Plasminogen Activator Inhibitor-1 (Recombinant) |
|
20-abx073514 |
Abbexa |
-
EUR 4519.20
-
EUR 393.60
-
EUR 276.00
|
|
|
|
 Plasminogen Activator Inhibitor-1 Enzyme |
|
20-abx073550 |
Abbexa |
-
EUR 393.60
-
EUR 5388.00
-
EUR 276.00
|
|
|
|
 Human HGF Activator, HGFAC ELISA Kit |
|
DEIA253 |
Creative Diagnostics |
5 plates |
EUR 1633.2 |
|
Description: The human HGFAC ELISA kit is for the quantitative determination of human HGFAC. |
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
) Plasminogen Activator Inhibitor 1 (PAI-1) |
|
5-01773 |
CHI Scientific |
4 x 5mg |
Ask for price |
) Plasminogen activator inhibitor 2 type A Antibody (HRP) |
|
20-abx109018 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
) Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
|
20-abx106186 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
) Plasminogen activator inhibitor 2 type A Antibody (FITC) |
|
20-abx107600 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 ELISA Kit) Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-b-48T |
DL Develop |
48T |
EUR 591.6 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-b-96T |
DL Develop |
96T |
EUR 769.2 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-c-48T |
DL Develop |
48T |
EUR 568.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids. |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-c-96T |
DL Develop |
96T |
EUR 736.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids. |
 ELISA Kit) Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Hu-48T |
DL Develop |
48T |
EUR 397.2 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Hu-96T |
DL Develop |
96T |
EUR 501.6 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-p-48T |
DL Develop |
48T |
EUR 656.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-p-96T |
DL Develop |
96T |
EUR 858 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
 ELISA Kit) Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Ra-48T |
DL Develop |
48T |
EUR 544.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Ra-96T |
DL Develop |
96T |
EUR 704.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Rb-48T |
DL Develop |
48T |
EUR 544.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Rb-96T |
DL Develop |
96T |
EUR 704.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 619.2 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 859.2 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-c-48Tests |
Reddot Biotech |
48 Tests |
EUR 591.6 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-c-96Tests |
Reddot Biotech |
96 Tests |
EUR 819.6 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 390 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 530.4 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-p-48Tests |
Reddot Biotech |
48 Tests |
EUR 696 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-p-96Tests |
Reddot Biotech |
96 Tests |
EUR 968.4 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 564 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 781.2 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 564 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 781.2 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 592.8 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 820.8 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-c-48Tests |
Reddot Biotech |
48 Tests |
EUR 566.4 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-c-96Tests |
Reddot Biotech |
96 Tests |
EUR 783.6 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 373.2 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 508.8 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-p-48Tests |
Reddot Biotech |
48 Tests |
EUR 666 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-p-96Tests |
Reddot Biotech |
96 Tests |
EUR 925.2 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 540 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 746.4 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 540 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 746.4 |
 ELISA Kit) Mouse Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit |
|
20-abx154500 |
Abbexa |
-
EUR 7970.40
-
EUR 4250.40
-
EUR 990.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
Mouse Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit |
|
abx254320-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
|
 CLIA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI1) CLIA Kit |
|
20-abx491602 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 ELISA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
DLR-PAI1-Mu-48T |
DL Develop |
48T |
EUR 586.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma or other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
DLR-PAI1-Mu-96T |
DL Develop |
96T |
EUR 762 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma or other biological fluids. |
 ELISA kit for Mouse Plasminogen activator inhibitor 1 |
|
EK1884 |
SAB |
96 tests |
EUR 562.8 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Plasminogen activator inhibitor 1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
 Mouse Serpine1/ Plasminogen activator inhibitor 1 ELISA Kit |
|
E1332Mo |
Sunlong |
1 Kit |
EUR 655.2 |
 Mouse Plasminogen activator inhibitor 1,PAI ELISA Kit |
|
ELA-E0532m |
Lifescience Market |
96 Tests |
EUR 1038 |
 Polyclonal Antibody (Mouse)) Plasminogen Activator Inhibitor 1 (PAI1) Polyclonal Antibody (Mouse) |
|
4-PAA532Mu01 |
Cloud-Clone |
-
EUR 283.20
-
EUR 2805.60
-
EUR 703.20
-
EUR 352.80
-
EUR 250.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Plasminogen Activator Inhibitor 1 (PAI1) |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5269.39 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 539.12 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 718.75 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2874.38 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
4-SEA532Mu |
Cloud-Clone |
-
EUR 5330.40
-
EUR 2815.20
-
EUR 718.80
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RD-PAI1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 586.8 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RD-PAI1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 812.4 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RDR-PAI1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 613.2 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RDR-PAI1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 850.8 |
) Mouse Plasminogen Activator Inhibitor 1 ELISA Kit (PAI1) |
|
RK03098 |
Abclonal |
96 Tests |
EUR 625.2 |
 CLIA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI-1) CLIA Kit |
|
abx197480-96tests |
Abbexa |
96 tests |
EUR 990 |
|
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Mouse plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
|
CSB-E07947m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Mouse plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
 Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
|
CN-02349M1 |
ChemNorm |
96T |
EUR 558 |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
|
CN-02349M2 |
ChemNorm |
48T |
EUR 378 |
 Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
|
E03P0889-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
|
E03P0889-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
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Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
|
E03P0889-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
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Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 ELISA Kit) Mouse PAI-1(Plasminogen Activator Inhibitor 1) ELISA Kit |
|
EM1262 |
FN Test |
96T |
EUR 628.92 |
|
|
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Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
ELISA Kit) Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
GA-E0101MS-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
GA-E0101MS-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
QY-E21194 |
Qayee Biotechnology |
96T |
EUR 495.6 |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
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YLA0640MO-48T |
Shanghai YL Biotech |
48T |
EUR 465 |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
|
YLA0640MO-96T |
Shanghai YL Biotech |
96T |
EUR 600 |
 Rabbit plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
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1-CSB-E06978Rb |
Cusabio |
-
EUR 1160.40
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EUR 7110.00
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EUR 3760.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
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Description: Quantitativecompetitive ELISA kit for measuring Rabbit plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Human plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
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1-CSB-E07946h |
Cusabio |
-
EUR 1080.00
-
EUR 6571.20
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Human plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Pig plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
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1-CSB-E06534p |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
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EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
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Description: Quantitativesandwich ELISA kit for measuring Pig plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 HPGDS inhibitor 1 |
|
B1046-1 |
ApexBio |
1 mg |
EUR 217.2 |
|
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation. |
 Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03574 |
CHI Scientific |
5µg |
Ask for price |
Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03575 |
CHI Scientific |
25µg |
Ask for price |
Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03576 |
CHI Scientific |
1mg |
Ask for price |
 Antibody) Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody |
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20-abx132062 |
Abbexa |
-
EUR 493.20
-
EUR 1262.40
-
EUR 627.60
-
EUR 184.80
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EUR 343.20
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Right here we present that pharmacological inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, and enhances GLUT4 translocation to the cytoplasmic membrane and that by activating tumor suppressor p53, will increase the expression of GDF15, a cytokine that reduces urge for food and prolongs lifespan. As well as, much like the antidiabetic drug metformin, we noticed that in db/db mice, DHODH inhibitors elevate ranges of circulating GDF15 and scale back meals consumption. Additional evaluation utilizing this mannequin for obesity-induced diabetes revealed that DHODH inhibitors delay pancreatic β cell demise and enhance metabolic steadiness.
