The simple synthesis of aminoribosyl uridines substituted by a 5′-methylene-urea is described. Their convergent synthesis entails the urea formation from numerous activated amides and an azidoribosyl uridine substituted on the 5′ place by an aminomethyl group. This widespread intermediate resulted from the diastereoselective glycosylation of a phthalimido uridine spinoff with a ribosyl fluoride as a ribosyl donor. The inhibition of the MraY transferase exercise by the synthetized 11 urea-containing inhibitors was evaluated and 10 compounds revealed MraY inhibition with IC50 starting from 1.9 μM to 16.7 μM. Their antibacterial exercise was additionally evaluated on a panel of Gram-positive and Gram-negative micro organism.
4 compounds exhibited a very good exercise in opposition to Gram-positive bacterial pathogens with MIC starting from eight to 32 μg mL-1, together with methicillin resistant Staphylococcus aureus (MRSA) and Enterococcus faecium. Curiously, one compound additionally revealed antibacterial exercise in opposition to Pseudomonas aeruginosa with MIC equal to 64 μg mL-1. Docking experiments predicted two modes of positioning of the lively compounds urea chain in numerous hydrophobic areas (HS2 and HS4) inside the MraY lively web site from Aquifex aeolicus. Nonetheless, molecular dynamics simulations confirmed that the urea chain adopts a binding mode much like that noticed in 5CKR structural mannequin and targets the hydrophobic space HS2.
Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically concerned in antimetastatic impact of melatonin in colorectal cancers
Within the present research, the underlying anti-metastatic mechanism of melatonin contained in some edible crops was explored in affiliation with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal most cancers cells. Right here, TMPRSS4 was extremely expressed in HCT15, however was weakly expressed in SW620 cells.
Melatonin exerted weak cytotoxicity, decreased invasion, adhesion, and migration, and attenuated the expression of TMPRSS4, cyclin E, pro-urokinase-type plasminogen activator (pro-uPA), p-signal transducer and activator of transcription 3 (p-STAT3), p-focal adhesion kinase (p-FAK), Snail and elevated the expression of E-cadherin, p27, pp38 and p-Jun N-terminal kinases (p-JNK) in HCT15 cells. Conversely, overexpression of TMPRSS4 lowered the flexibility of melatonin to activate E-cadherin and scale back Snail.
Moreover, even in SW620 cells transfected with TMPRSS4-overexpression plasmid, melatonin successfully suppressed invasion and migration together with decreased expression of Snail, cyclin A, cyclin E, pro-uPA and p-FAK and elevated expression of E-cadherin and p27. Total, these findings present proof that melatonin suppresses metastasis in colon most cancers cells by way of inhibition of TMPRSS4 mediated EMT.
POSTMEAL OPTOGENETIC INHIBITION OF DORSAL HIPPOCAMPAL PRINCIPAL NEURONS INCREASES FUTURE INTAKE IN A TIME-DEPENDENT MANNER
Analysis involving human members signifies that recollections of lately eaten meals restrict how a lot is eaten throughout subsequent consuming episodes; but, the mind areas that mediate the inhibitory results of ingestion-related reminiscence on future consumption are largely unknown. We hypothesize that dorsal hippocampal (dHC) neurons, that are essential for episodic recollections of private experiences, mediate the inhibitory results of ingestion-related reminiscence on future consumption. Our analysis program geared toward testing this speculation has been influenced largely by our mentor James McGaugh and his analysis on posttraining manipulations.
Within the current research, we used an activity-guided optogenetic strategy to check the prediction that if dHC glutamatergic neurons restrict future consumption by way of a course of that requires reminiscence consolidation, then inhibition ought to enhance subsequent consumption when given quickly after the tip of a meal however delayed inhibition should not have any impact.
Viral vectors containing CaMKIIα-eArchT3.0-eYFP and fiber optic probes had been positioned within the dHC of male Sprague-Dawley rats. In comparison with consumption on a day when no inhibition was given, postmeal inhibition of dHC glutamatergic neurons given for 10 min after the tip of a saccharin meal elevated the chance that rats would eat a second meal 90 min later and considerably elevated the quantity of saccharin resolution consumed throughout that subsequent meal when the neurons had been not inhibited.
Importantly, delayed inhibition given 80 min after the tip of the saccharin meal didn’t have an effect on subsequent consumption of saccharin. On condition that saccharin has minimal postingestive gastric penalties, these results aren’t seemingly because of the timing of interoceptive visceral cues generated by the meal. These knowledge present that dHC glutamatergic neural exercise is critical throughout the early postprandial interval for limiting future consumption and counsel that these neurons inhibit future consumption by consolidating the reminiscence of the previous meal.
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic steadiness
Dihydroorotate dehydrogenase (DHODH) is important for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been lengthy used to deal with autoimmune ailments and are in medical trials for most cancers and viral infections. Curiously, DHODH is positioned within the interior mitochondrial membrane and contributes to offer ubiquinol to the respiratory chain. Thus, DHODH supplies the hyperlink between nucleotide metabolism and mitochondrial perform.
 SERPINE1 Plasminogen Activator Inhibitor-1 Human Recombinant Protein |
|
PROTP05121-1 |
BosterBio |
Regular: 25ug |
EUR 317 |
|
Description: SERPINE1 Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (24-402) and having a molecular mass of 45 kDa.;The SERPINE1 is purified by proprietary chromatographic techniques. |
, hexapeptide, Human) Plasminogen Activator Inhibitor 1 (PAI-1), hexapeptide, Human |
|
SP-55196-1 |
Alpha Diagnostics |
0.5 mg |
EUR 141 |
 AssayMax ELISA Kit) Human Plasminogen Activator Inhibitor-1 (PAI-1) AssayMax ELISA Kit |
|
EP1100-1 |
AssayPro |
96 Well Plate |
EUR 417 |
 ELISA Kit) Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Mu-48T |
DL Develop |
48T |
EUR 435 |
- Should the Mouse Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Mu-96T |
DL Develop |
96T |
EUR 561 |
- Should the Mouse Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 447 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 618 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 429 |
Mouse Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 591 |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280 |
) Mouse Plasminogen activator inhibitor 1 (Serpine1) |
|
1-CSB-EP021081MO |
Cusabio |
-
EUR 505.00
-
EUR 265.00
-
EUR 1827.00
-
EUR 766.00
-
EUR 1218.00
-
EUR 335.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 58.9 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Mouse Plasminogen activator inhibitor 1(Serpine1) expressed in E.coli |
Mouse Plasminogen activator inhibitor 1 (Serpine1) |
|
1-CSB-YP021081MO |
Cusabio |
-
EUR 504.00
-
EUR 265.00
-
EUR 1832.00
-
EUR 763.00
-
EUR 1216.00
-
EUR 334.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 44.9 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Mouse Plasminogen activator inhibitor 1(Serpine1) expressed in Yeast |
 anti-HGF |
|
YF-PA12302 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to HGF |
anti-HGF |
|
YF-PA23875 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to HGF |
 Antibody) Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Antibody |
|
20-abx142242 |
Abbexa |
-
EUR 370.00
-
EUR 606.00
-
EUR 314.00
|
|
- Shipped within 5-10 working days.
|
 Plasminogen activator inhibitor 2 type A Antibody |
|
20-abx109400 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 Human HGF Activator, HGFAC ELISA Kit |
|
DEIA253 |
Creative Diagnostics |
5 plates |
EUR 1361 |
|
Description: The human HGFAC ELISA kit is for the quantitative determination of human HGFAC. |
 Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 1 ELISA kit |
|
E03P0028-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Protein) Mouse Plasminogen Activator Inhibitor 1 (PAI1) Protein |
|
20-abx168332 |
Abbexa |
-
EUR 648.00
-
EUR 272.00
-
EUR 1943.00
-
EUR 759.00
-
EUR 467.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
- Shipped within 5-7 working days.
|
 Human Plasminogen Activator Inhibitor-1 |
|
7-03571 |
CHI Scientific |
2µg |
Ask for price |
Human Plasminogen Activator Inhibitor-1 |
|
7-03572 |
CHI Scientific |
10µg |
Ask for price |
Human Plasminogen Activator Inhibitor-1 |
|
7-03573 |
CHI Scientific |
1mg |
Ask for price |
) Plasminogen Activator Inhibitor-1 (Recombinant) |
|
20-abx073514 |
Abbexa |
-
EUR 3766.00
-
EUR 328.00
-
EUR 230.00
|
|
- Shipped within 5-10 working days.
|
 Plasminogen Activator Inhibitor-1 Enzyme |
|
20-abx073550 |
Abbexa |
-
EUR 328.00
-
EUR 4490.00
-
EUR 230.00
|
|
- Shipped within 5-10 working days.
|
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
) Plasminogen Activator Inhibitor 1 (PAI-1) |
|
5-01773 |
CHI Scientific |
4 x 5mg |
Ask for price |
) Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
|
1-CSB-EP021070RA |
Cusabio |
-
EUR 505.00
-
EUR 265.00
-
EUR 1827.00
-
EUR 766.00
-
EUR 1218.00
-
EUR 335.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 63.2 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in E.coli |
Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
|
1-CSB-YP021070RA |
Cusabio |
-
EUR 504.00
-
EUR 265.00
-
EUR 1832.00
-
EUR 763.00
-
EUR 1216.00
-
EUR 334.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 49.2 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in Yeast |
) Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
|
20-abx106186 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
) Plasminogen activator inhibitor 2 type A Antibody (FITC) |
|
20-abx107600 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
) Plasminogen activator inhibitor 2 type A Antibody (HRP) |
|
20-abx109018 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
 ELISA Kit) Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-b-48T |
DL Develop |
48T |
EUR 493 |
- Should the Bovine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-b-96T |
DL Develop |
96T |
EUR 641 |
- Should the Bovine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-c-48T |
DL Develop |
48T |
EUR 474 |
- Should the Canine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids. |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-c-96T |
DL Develop |
96T |
EUR 614 |
- Should the Canine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids. |
 ELISA Kit) Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Hu-48T |
DL Develop |
48T |
EUR 331 |
- Should the Human Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Hu-96T |
DL Develop |
96T |
EUR 418 |
- Should the Human Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-p-48T |
DL Develop |
48T |
EUR 547 |
- Should the Porcine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-p-96T |
DL Develop |
96T |
EUR 715 |
- Should the Porcine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
 ELISA Kit) Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Ra-48T |
DL Develop |
48T |
EUR 454 |
- Should the Rat Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Ra-96T |
DL Develop |
96T |
EUR 587 |
- Should the Rat Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
 ELISA Kit) Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Rb-48T |
DL Develop |
48T |
EUR 454 |
- Should the Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
DLR-HGF-Rb-96T |
DL Develop |
96T |
EUR 587 |
- Should the Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 516 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 716 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-c-48Tests |
Reddot Biotech |
48 Tests |
EUR 493 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-c-96Tests |
Reddot Biotech |
96 Tests |
EUR 683 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 325 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 442 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-p-48Tests |
Reddot Biotech |
48 Tests |
EUR 580 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-p-96Tests |
Reddot Biotech |
96 Tests |
EUR 807 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 470 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 651 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 470 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RDR-HGF-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 651 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-b-48Tests |
Reddot Biotech |
48 Tests |
EUR 494 |
Bovine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-b-96Tests |
Reddot Biotech |
96 Tests |
EUR 684 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-c-48Tests |
Reddot Biotech |
48 Tests |
EUR 472 |
Canine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-c-96Tests |
Reddot Biotech |
96 Tests |
EUR 653 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 311 |
Human Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 424 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-p-48Tests |
Reddot Biotech |
48 Tests |
EUR 555 |
Porcine Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-p-96Tests |
Reddot Biotech |
96 Tests |
EUR 771 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 450 |
Rat Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 622 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Rb-48Tests |
Reddot Biotech |
48 Tests |
EUR 450 |
Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit |
|
RD-HGF-Rb-96Tests |
Reddot Biotech |
96 Tests |
EUR 622 |
 Anti-HGF Antibody |
|
PA1312 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-HGF Antibody |
|
PB9084 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-HGF Antibody |
|
RP1062 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-HGF antibody |
|
STJ23940 |
St John's Laboratory |
100 µl |
EUR 277 |
|
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. |
Anti-HGF antibody |
|
STJ97652 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to HGF. |
 Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
|
E03P0889-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
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E03P0889-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
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Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA kit |
|
E03P0889-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor 1,PAI-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 CLIA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI-1) CLIA Kit |
|
abx197480-96tests |
Abbexa |
96 tests |
EUR 825 |
- Shipped within 5-12 working days.
|
 Mouse plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
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CSB-E07947m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
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Description: Quantitativesandwich ELISA kit for measuring Mouse plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse plasminogen activator inhibitor 1, PAI-1 ELISA Kit |
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1-CSB-E07947m |
Cusabio |
-
EUR 946.00
-
EUR 5782.00
-
EUR 3060.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
- Sample volume: 50-100ul
- Detection wavelength: 450nm
- Assay performance time: 1 to 4 hours.
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Description: Quantitativesandwich ELISA kit for measuring Mouse plasminogen activator inhibitor 1, PAI-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
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CN-02349M1 |
ChemNorm |
96T |
EUR 465 |
Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit |
|
CN-02349M2 |
ChemNorm |
48T |
EUR 315 |
 ELISA Kit) Mouse PAI-1(Plasminogen Activator Inhibitor 1) ELISA Kit |
|
EM1262 |
FN Test |
96T |
EUR 524.1 |
- Detection range: 0.156-10 ng/ml
- Uniprot ID: P22777
- Alias: Serpine1/PAI-1/PAI1/SERPINE1/Nexin/PLANH1/Endothelial plasminogen activator inhibitor/PAISerpin E1/PLANH1/plasminogen activator inhibitor 1/serine(or cysteine) proteinase inhibitor, clade E(ne
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Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
ELISA Kit) Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
GA-E0101MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
GA-E0101MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
Mouse plasminogen activator inhibitor 1(PAI-1)ELISA Kit |
|
QY-E21194 |
Qayee Biotechnology |
96T |
EUR 413 |
 ELISA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
DLR-PAI1-Mu-48T |
DL Develop |
48T |
EUR 489 |
- Should the Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma or other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
DLR-PAI1-Mu-96T |
DL Develop |
96T |
EUR 635 |
- Should the Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma or other biological fluids. |
 ELISA Kit) Mouse Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit |
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20-abx154500 |
Abbexa |
-
EUR 6642.00
-
EUR 3542.00
-
EUR 825.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
- Shipped within 5-7 working days.
|
Mouse Plasminogen Activator Inhibitor 1 (SERPINE1) ELISA Kit |
|
abx254320-96tests |
Abbexa |
96 tests |
EUR 668 |
- Shipped within 5-12 working days.
|
 ELISA kit for Mouse Plasminogen activator inhibitor 1 |
|
EK1884 |
SAB |
96 tests |
EUR 469 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Plasminogen activator inhibitor 1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
 Mouse Plasminogen activator inhibitor 1,PAI ELISA Kit |
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ELA-E0532m |
Lifescience Market |
96 Tests |
EUR 865 |
 Mouse Serpine1/ Plasminogen activator inhibitor 1 ELISA Kit |
|
E1332Mo |
Sunlong |
1 Kit |
EUR 546 |
 CLIA Kit) Mouse Plasminogen Activator Inhibitor 1 (PAI1) CLIA Kit |
|
20-abx491602 |
Abbexa |
-
EUR 7973.00
-
EUR 4246.00
-
EUR 981.00
|
-
10 × 96 tests
-
5 × 96 tests
-
96 tests
|
|
|
 Polyclonal Antibody (Mouse)) Plasminogen Activator Inhibitor 1 (PAI1) Polyclonal Antibody (Mouse) |
|
4-PAA532Mu01 |
Cloud-Clone |
-
EUR 236.00
-
EUR 2338.00
-
EUR 586.00
-
EUR 294.00
-
EUR 209.00
|
-
100ul
-
10ml
-
1ml
-
200ul
-
20ul
|
- Sequence of the immunogen: PAI1 (Gln141~Pro389)
- Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
|
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Description: A Rabbit polyclonal antibody against Mouse Plasminogen Activator Inhibitor 1 (PAI1) |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4391.16 |
- The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 1 (PAI1) were tested on 3 different plates, 8 replicates in each plate
- CV(%) = SD/meanX100
- Intra-Assay: CV<10%
- Inter-As
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 449.27 |
- The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 1 (PAI1) were tested on 3 different plates, 8 replicates in each plate
- CV(%) = SD/meanX100
- Intra-Assay: CV<10%
- Inter-As
- Show more
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 598.96 |
- The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 1 (PAI1) were tested on 3 different plates, 8 replicates in each plate
- CV(%) = SD/meanX100
- Intra-Assay: CV<10%
- Inter-As
- Show more
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
SEA532Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2395.32 |
- The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 1 (PAI1) were tested on 3 different plates, 8 replicates in each plate
- CV(%) = SD/meanX100
- Intra-Assay: CV<10%
- Inter-As
- Show more
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in serum, plasma and other biological fluids. |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
4-SEA532Mu |
Cloud-Clone |
-
EUR 4442.00
-
EUR 2346.00
-
EUR 599.00
|
-
10 plates of 96 wells
-
5 plates of 96 wells
-
1 plate of 96 wells
|
- Known also as Plasminogen Activator Inhibitor 1 elisa. Alternative names of the recognized antigen: SERPINE1
- PLANH1
- Serpin Peptidase Inhibitor Clade E Member 1
- Nexin, Plasminogen Activator Inhibitor Type 1 Serpin E1
- Endothelial plasminogen activa
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Plasminogen Activator Inhibitor 1 (PAI1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
) Mouse Plasminogen Activator Inhibitor 1 ELISA Kit (PAI1) |
|
RK03098 |
Abclonal |
96 Tests |
EUR 521 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RDR-PAI1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RDR-PAI1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RD-PAI1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 489 |
Mouse Plasminogen Activator Inhibitor 1 (PAI1) ELISA Kit |
|
RD-PAI1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 677 |
 HPGDS inhibitor 1 |
|
B1046-1 |
ApexBio |
1 mg |
EUR 181 |
|
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation. |
 Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03574 |
CHI Scientific |
5µg |
Ask for price |
Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03575 |
CHI Scientific |
25µg |
Ask for price |
Recobinant Human Plasminogen Activator Inhibitor-1 |
|
7-03576 |
CHI Scientific |
1mg |
Ask for price |
) Rat Plasminogen activator inhibitor 1 (Serpine1) |
|
1-CSB-EP021081RA |
Cusabio |
-
EUR 505.00
-
EUR 265.00
-
EUR 1827.00
-
EUR 766.00
-
EUR 1218.00
-
EUR 335.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 58.6 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
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Description: Recombinant Rat Plasminogen activator inhibitor 1(Serpine1) expressed in E.coli |
Right here we present that pharmacological inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, and enhances GLUT4 translocation to the cytoplasmic membrane and that by activating tumor suppressor p53, will increase the expression of GDF15, a cytokine that reduces urge for food and prolongs lifespan. As well as, much like the antidiabetic drug metformin, we noticed that in db/db mice, DHODH inhibitors elevate ranges of circulating GDF15 and scale back meals consumption. Additional evaluation utilizing this mannequin for obesity-induced diabetes revealed that DHODH inhibitors delay pancreatic β cell demise and enhance metabolic steadiness.
