Subsequent attempt tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia; a single institute experience

August 12, 2021 Leave a comment
Discontinuation of tyrosine kinase inhibitors (TKIs) is now a possible therapeutic aim for sufferers with continual section continual myeloid leukemia (CML-CP). Whereas roughly half of sufferers expertise molecular relapse, after resuming with any TKI; the bulk re-achieve a deep molecular response (DMR). It’s unclear whether or not such sufferers who re-achieve a sturdy DMR can discontinue TKI safely once more. Right here, we retrospectively assessed first, second, and third makes an attempt to cease TKIs in sufferers with CML-CP.
On the first try, 28 out of a complete of 53 sufferers achieved sustained treatment-free remission (TFR; 53.4%; 95% confidence interval [CI], 39.0%-65.9%). Subsequently, 10 of 25 sufferers tried a second TKI discontinuation, and in all circumstances, this was after receiving second-generation TKIs. 4 of 10 sufferers efficiently achieved TFR (37.5%; 95% CI, 9.9%-65.9%). All sufferers who relapsed on the second TKI discontinuation try had been re-administered TKIs, and shortly achieved not less than a significant molecular remission. All six second relapse sufferers had a lack of MR4.5 at three months after TKI discontinuation. These findings counsel that second and third makes an attempt to efficiently cease TKI remedy are possible in sufferers with CML-CP.

Identification of the FDA-approved drug Pyrvinium as a small-molecule inhibitor of PD-1/PD-L1 interplay

Immune checkpoint blockade involving inhibition of the PD-1/PD-L1 interplay has offered unprecedented medical advantages in treating a wide range of tumors. So far, a complete of six antibodies that bind to both PD-1 or PD-L1 protein and in flip inhibit the PD-1/PD-L1 interplay have obtained medical approvals. Regardless of being extremely efficient, these costly giant biotherapeutics possess a number of inherent pharmacokinetic limitations that may be efficiently overcome by way of the usage of low-molecular-weight inhibitors. One such promising strategy entails small-molecule induced dimerization and sequestration of PD-L1, resulting in efficient PD-1/PD-L1 inhibition.
Herein, we current discovery of such potential bioactive PD-L1 dimerizers by way of a structure- and ligand-based screening of a targeted library of accredited and investigational medicine worldwide. Pyrvinium, an FDA-approved anthelmintic drug, confirmed the best exercise in our research with IC50 worth of ~29.66 µM. It’s noteworthy that Pyrvinium, being an accredited drug, might show particularly appropriate as an excellent place to begin for additional medicinal chemistry efforts, resulting in design and growth of much more potent structural analogs as selective PD-1/PD-L1 inhibitors. Moreover, the adopted built-in digital screening protocol might show helpful in screening different bigger databases of lead- and drug-like molecules for hit identification within the area of small-molecule PD-1/PD-L1 inhibitors.

Posterior Reversible Encephalopathy Syndrome (PRES) and Drug-Induced Hypersensitivity Syndrome (DIHS) following Immunotherapy and BRAF/MEK Inhibition with Continued Response in Metastatic Melanoma

Background. The function of immunotherapy continues to evolve throughout each strong and hematologic malignancies. Nonetheless, whereas use of immunotherapy has elevated through the arrival of checkpoint inhibition, chimeric antigen receptors, and vaccines towards malignant cells, there stays uncertainty relating to the popularity and administration of delayed immune-related reactions and publish remedy immune-related sensitivity to subsequent medicines, comparable to BRAF/MEK kinase inhibitors. Moreover, it’s unclear how immunotherapy might alter the antagonistic impact profile and efficacy of subsequent traces of remedy. Case Presentation.
Subsequent attempt tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia; a single institute experience
Mentioned is a affected person with stage IV metastatic melanoma who failed first-line remedy with a mixture of nivolumab and ipilimumab. He was then handled with BRAF/MEK kinase inhibition through Encorafenib and Binimetinib. Shortly thereafter, the affected person developed posterior reversible encephalopathy syndrome (PRES) and a generalized pruritic rash that was biopsied with consideration towards drug response versus drug-induced hypersensitivity syndrome (DIHS), previously referred to as drug response with eosinophilia and systemic signs (DRESS). The BRAF/MEK mixture was held and steroid taper initiated with continued response even past conclusion of the steroid taper. Dialogue and Conclusions. This case highlights the diagnostic problem offered by PRES and DIHS within the setting of immunotherapy and BRAF/MEK kinase inhibition for malignant melanoma.
The medical rationale for reinitiating remedy following extreme immune reactions subsequent to immunotherapy within the setting of relapsed/refractory metastatic melanoma is mentioned. Moreover, the sturdy response our affected person skilled all through the drug maintain interval and steroid taper and its medical potential etiologies and purposes are reviewed. As checkpoint inhibition and tyrosine-kinase inhibitors have turn into cornerstones of most cancers remedy, bigger research and long-term observations are wanted to research the dangers and advantages throughout completely different sequences of remedy.

Dietary composition and proteomic evaluation of soft-shelled turtle (Pelodiscus sinensis) egg and identification of oligopeptides with alpha-glucosidase inhibitory exercise

This research aimed to discover dietary compositions and proteomics of soft-shelled turtle (SST) egg, in addition to establish potential antidiabetic oligopeptides with α-glucosidase inhibitory property. Outcomes revealed that SST egg is a promising supply of extremely nutritious proteins and minerals (54.64% and 5.81% of dry matter, respectively). Additional proteomic evaluation confirmed SST egg proteins contained not less than 9 protein households, comparable to transferrin/iron binding protein and immunoregulation-related protein. Hydrolysis by completely different enzymes, particularly papain, remarkably elevated α-glucosidase inhibitory exercise and scavenging exercise for ABTS, DPPH, hydroxyl and oxygen radicals of SST egg proteins.

Rat Plasminogen activator inhibitor 2 type A (Serpinb2)
1-CSB-EP021070RA
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 63.2 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in E.coli

Rat Plasminogen activator inhibitor 2 type A (Serpinb2)
1-CSB-YP021070RA
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 49.2 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in Yeast

Plasminogen activator inhibitor 2 type A Antibody (Biotin)
20-abx106186
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Plasminogen activator inhibitor 2 type A Antibody (FITC)
20-abx107600
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Plasminogen activator inhibitor 2 type A Antibody (HRP)
20-abx109018
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Mu-48T 48T
EUR 435
  • Should the Mouse Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Mu-96T 96T
EUR 561
  • Should the Mouse Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Mu-48Tests 48 Tests
EUR 447

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Mu-96Tests 96 Tests
EUR 618

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Mu-48Tests 48 Tests
EUR 429

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Mu-96Tests 96 Tests
EUR 591

Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) Antibody
20-abx142243
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

anti-HGF
YF-PA12302 100 ug
EUR 403
Description: Rabbit polyclonal to HGF

anti-HGF
YF-PA23875 50 ul
EUR 334
Description: Mouse polyclonal to HGF

Sheep anti-Human Plasminogen Activator Inhibitor Type 1 polyclonal antibody
CABT-L494 10 mg
EUR 538

Sheep anti-Human Plasminogen Activator Inhibitor Type 1 polyclonal antibody
CABT-L495 200ug
EUR 715

Mouse Plasminogen Activator Inhibitor 2 ELISA kit
E03P0057-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plasminogen Activator Inhibitor 2 ELISA kit
E03P0057-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plasminogen Activator Inhibitor 2 ELISA kit
E03P0057-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) Protein
20-abx068563
  • EUR 704.00
  • EUR 286.00
  • EUR 2193.00
  • EUR 843.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human HGF Activator, HGFAC ELISA Kit
DEIA253 5 plates
EUR 1361
Description: The human HGFAC ELISA kit is for the quantitative determination of human HGFAC.

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

Mouse Plasminogen Activator Inhibitor 2 (PAI-2) CLIA Kit
abx197483-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Mouse PAI-2(Plasminogen Activator Inhibitor 2) ELISA Kit
EM1263 96T
EUR 524.1
  • Detection range: 0.391-25 ng/ml
  • Uniprot ID: P12388
  • Alias: PAI-2/PLANH2/Urokinase Inhibitor/HsT1201/Monocyte Arg-serpin/PAI/PAI2Urokinase inhibitor/Placental plasminogen activator inhibitor/PLANH2PAI-2/plasminogen activator inhibitor 2/plasminogen act
  • Show more
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.234 ng/ml

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-b-48T 48T
EUR 493
  • Should the Bovine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-b-96T 96T
EUR 641
  • Should the Bovine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-c-48T 48T
EUR 474
  • Should the Canine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids.

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-c-96T 96T
EUR 614
  • Should the Canine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Canine Hepatocyte Growth Factor (HGF) in samples from serum, plasma or other biological fluids.

Human Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Hu-48T 48T
EUR 331
  • Should the Human Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Hu-96T 96T
EUR 418
  • Should the Human Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-p-48T 48T
EUR 547
  • Should the Porcine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-p-96T 96T
EUR 715
  • Should the Porcine Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Ra-48T 48T
EUR 454
  • Should the Rat Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Ra-96T 96T
EUR 587
  • Should the Rat Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Rb-48T 48T
EUR 454
  • Should the Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
DLR-HGF-Rb-96T 96T
EUR 587
  • Should the Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-b-48Tests 48 Tests
EUR 516

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-b-96Tests 96 Tests
EUR 716

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-c-48Tests 48 Tests
EUR 493

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-c-96Tests 96 Tests
EUR 683

Human Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Hu-48Tests 48 Tests
EUR 325

Human Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Hu-96Tests 96 Tests
EUR 442

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-p-48Tests 48 Tests
EUR 580

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-p-96Tests 96 Tests
EUR 807

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Ra-48Tests 48 Tests
EUR 470

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Ra-96Tests 96 Tests
EUR 651

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Rb-48Tests 48 Tests
EUR 470

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
RDR-HGF-Rb-96Tests 96 Tests
EUR 651

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-b-48Tests 48 Tests
EUR 494

Bovine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-b-96Tests 96 Tests
EUR 684

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-c-48Tests 48 Tests
EUR 472

Canine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-c-96Tests 96 Tests
EUR 653

Human Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Hu-48Tests 48 Tests
EUR 311

Human Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Hu-96Tests 96 Tests
EUR 424

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-p-48Tests 48 Tests
EUR 555

Porcine Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-p-96Tests 96 Tests
EUR 771

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Ra-48Tests 48 Tests
EUR 450

Rat Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Ra-96Tests 96 Tests
EUR 622

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Rb-48Tests 48 Tests
EUR 450

Rabbit Hepatocyte Growth Factor (HGF) ELISA Kit
RD-HGF-Rb-96Tests 96 Tests
EUR 622

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
DLR-PAI2-Mu-48T 48T
EUR 489
  • Should the Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in samples from plasma.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
DLR-PAI2-Mu-96T 96T
EUR 635
  • Should the Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in samples from plasma.

Mouse Plasminogen activator inhibitor 2(SERPINB2) ELISA kit
CSB-EL021070MO-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Plasminogen activator inhibitor 2 (SERPINB2) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Plasminogen activator inhibitor 2(SERPINB2) ELISA kit
1-CSB-EL021070MO
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Plasminogen activator inhibitor 2(SERPINB2) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) ELISA Kit
20-abx154501
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) ELISA Kit
abx254321-96tests 96 tests
EUR 754
  • Shipped within 5-12 working days.

Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) ELISA Kit
abx572225-96tests 96 tests
EUR 754
  • Shipped within 5-12 working days.

Mouse Plasminogen Activator Inhibitor 2 (SERPINB2) CLIA Kit
20-abx491599
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Plasminogen Activator Inhibitor 2 (PAI2) Polyclonal Antibody (Mouse)
4-PAA531Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PAI2 (Ile68~Lys313)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Plasminogen Activator Inhibitor 2 (PAI2)

SERPINE2 Plasminogen Activator Inhibitor-2 Mouse Recombinant Protein
PROTQ07235 Regular: 10ug
EUR 317
Description: SERPINE2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 386 amino acids (20-397a.a.) andhaving a molecular mass of 42.9kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).SERPINE2 is expressed with a 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
SEA531Mu-10x96wellstestplate 10x96-wells test plate
EUR 4391.16
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 2 (PAI2) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-As
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
SEA531Mu-1x48wellstestplate 1x48-wells test plate
EUR 449.27
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 2 (PAI2) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-As
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
SEA531Mu-1x96wellstestplate 1x96-wells test plate
EUR 598.96
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 2 (PAI2) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-As
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
SEA531Mu-5x96wellstestplate 5x96-wells test plate
EUR 2395.32
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Plasminogen Activator Inhibitor 2 (PAI2) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-As
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
4-SEA531Mu
  • EUR 4442.00
  • EUR 2346.00
  • EUR 599.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Plasminogen Activator Inhibitor 2 elisa. Alternative names of the recognized antigen: SERPINB2
  • PLANH2
  • Serpin Peptidase Inhibitor Clade B Member 2
  • Monocyte Arg-serpin
  • Placental plasminogen activator inhibitor
  • Serpin B2
  • Urokinase in
  • Show more
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in samples from plasma with no significant corss-reactivity with analogues from other species.

Mouse Plasminogen Activator Inhibitor 2(PAI2)ELISA kit
QY-E21195 96T
EUR 413

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
RDR-PAI2-Mu-48Tests 48 Tests
EUR 511

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
RDR-PAI2-Mu-96Tests 96 Tests
EUR 709

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
RD-PAI2-Mu-48Tests 48 Tests
EUR 489

Mouse Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
RD-PAI2-Mu-96Tests 96 Tests
EUR 677

Anti-HGF Antibody
PA1312 100ug/vial
EUR 334

Anti-HGF Antibody
PB9084 100ug/vial
EUR 334

Anti-HGF Antibody
RP1062 100ug/vial
EUR 294

Anti-HGF antibody
STJ23940 100 µl
EUR 277
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

Anti-HGF antibody
STJ97652 200 µl
EUR 197
Description: Rabbit polyclonal to HGF.

Human Plasminogen activator inhibitor 2 (SERPINB2)
1-CSB-MP021070HU
  • EUR 293.00
  • EUR 963.00
  • EUR 409.00
  • EUR 717.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
  • MW: 50.1 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Plasminogen activator inhibitor 2(SERPINB2) expressed in Mammalian cell

Human Plasminogen activator inhibitor 2 (SERPINB2)
1-CSB-YP021070HU
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 48.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Plasminogen activator inhibitor 2(SERPINB2) expressed in Yeast

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx008899
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx178029
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug
  • Please enquire.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx103483
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx103484
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx103485
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx132061
  • EUR 328.00
  • EUR 843.00
  • EUR 439.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx174083
  • EUR 787.00
  • EUR 411.00
  • 1 mg
  • 200 ug
  • Please enquire.

Plasminogen Activator Inhibitor 2 (PAI2) Antibody
20-abx174084
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.

Recombinant human Plasminogen activator inhibitor 2
P1738 100ug Ask for price
  • Uniprot ID: P05120
  • Reconstitution: Metal affinity chromatography on Fn Super Capacity Column (Nickel)
Description: Recombinant protein for human Plasminogen activator inhibitor 2
Peptides from papain hydrolysate had been fractionated utilizing ultrafiltration adopted by reverse section chromatography, and 16 peptides had been recognized in probably the most lively fraction by LC-QTOF-MS/MS. Molecular docking revealed that 14 of those peptides might simply dock into the substrate-binding pocket and/or inhibitor binding websites of α-glucosidase with the docking rating beneath -150 kcal/mol, indicating their potential α-glucosidase inhibitory properties.
The 5 most considerable oligopeptides with potent interplay with α-glucosidase had been additional synthesized, and oligopeptides HNKPEVEVR, ARDASVLK and SGTLLHK strongly inhibited the exercise of α-glucosidase (IC50 of 56, 195 and 289 µmol/L, respectively). Subsequently, oligopeptides from enzymatic hydrolysate of SST egg protein exhibit potential antidiabetic exercise, making it a promising practical meals ingredient.

Leave a Reply

Your email address will not be published. Required fields are marked *