Discontinuation of tyrosine kinase inhibitors (TKIs) is now a possible therapeutic aim for sufferers with continual section continual myeloid leukemia (CML-CP). Whereas roughly half of sufferers expertise molecular relapse, after resuming with any TKI; the bulk re-achieve a deep molecular response (DMR). It’s unclear whether or not such sufferers who re-achieve a sturdy DMR can discontinue TKI safely once more. Right here, we retrospectively assessed first, second, and third makes an attempt to cease TKIs in sufferers with CML-CP.
On the first try, 28 out of a complete of 53 sufferers achieved sustained treatment-free remission (TFR; 53.4%; 95% confidence interval [CI], 39.0%-65.9%). Subsequently, 10 of 25 sufferers tried a second TKI discontinuation, and in all circumstances, this was after receiving second-generation TKIs. 4 of 10 sufferers efficiently achieved TFR (37.5%; 95% CI, 9.9%-65.9%). All sufferers who relapsed on the second TKI discontinuation try had been re-administered TKIs, and shortly achieved not less than a significant molecular remission. All six second relapse sufferers had a lack of MR4.5 at three months after TKI discontinuation. These findings counsel that second and third makes an attempt to efficiently cease TKI remedy are possible in sufferers with CML-CP.
Identification of the FDA-approved drug Pyrvinium as a small-molecule inhibitor of PD-1/PD-L1 interplay
Immune checkpoint blockade involving inhibition of the PD-1/PD-L1 interplay has offered unprecedented medical advantages in treating a wide range of tumors. So far, a complete of six antibodies that bind to both PD-1 or PD-L1 protein and in flip inhibit the PD-1/PD-L1 interplay have obtained medical approvals. Regardless of being extremely efficient, these costly giant biotherapeutics possess a number of inherent pharmacokinetic limitations that may be efficiently overcome by way of the usage of low-molecular-weight inhibitors. One such promising strategy entails small-molecule induced dimerization and sequestration of PD-L1, resulting in efficient PD-1/PD-L1 inhibition.
Herein, we current discovery of such potential bioactive PD-L1 dimerizers by way of a structure- and ligand-based screening of a targeted library of accredited and investigational medicine worldwide. Pyrvinium, an FDA-approved anthelmintic drug, confirmed the best exercise in our research with IC50 worth of ~29.66 µM. It’s noteworthy that Pyrvinium, being an accredited drug, might show particularly appropriate as an excellent place to begin for additional medicinal chemistry efforts, resulting in design and growth of much more potent structural analogs as selective PD-1/PD-L1 inhibitors. Moreover, the adopted built-in digital screening protocol might show helpful in screening different bigger databases of lead- and drug-like molecules for hit identification within the area of small-molecule PD-1/PD-L1 inhibitors.
Posterior Reversible Encephalopathy Syndrome (PRES) and Drug-Induced Hypersensitivity Syndrome (DIHS) following Immunotherapy and BRAF/MEK Inhibition with Continued Response in Metastatic Melanoma
Background. The function of immunotherapy continues to evolve throughout each strong and hematologic malignancies. Nonetheless, whereas use of immunotherapy has elevated through the arrival of checkpoint inhibition, chimeric antigen receptors, and vaccines towards malignant cells, there stays uncertainty relating to the popularity and administration of delayed immune-related reactions and publish remedy immune-related sensitivity to subsequent medicines, comparable to BRAF/MEK kinase inhibitors. Moreover, it’s unclear how immunotherapy might alter the antagonistic impact profile and efficacy of subsequent traces of remedy. Case Presentation.
Mentioned is a affected person with stage IV metastatic melanoma who failed first-line remedy with a mixture of nivolumab and ipilimumab. He was then handled with BRAF/MEK kinase inhibition through Encorafenib and Binimetinib. Shortly thereafter, the affected person developed posterior reversible encephalopathy syndrome (PRES) and a generalized pruritic rash that was biopsied with consideration towards drug response versus drug-induced hypersensitivity syndrome (DIHS), previously referred to as drug response with eosinophilia and systemic signs (DRESS). The BRAF/MEK mixture was held and steroid taper initiated with continued response even past conclusion of the steroid taper. Dialogue and Conclusions. This case highlights the diagnostic problem offered by PRES and DIHS within the setting of immunotherapy and BRAF/MEK kinase inhibition for malignant melanoma.
The medical rationale for reinitiating remedy following extreme immune reactions subsequent to immunotherapy within the setting of relapsed/refractory metastatic melanoma is mentioned. Moreover, the sturdy response our affected person skilled all through the drug maintain interval and steroid taper and its medical potential etiologies and purposes are reviewed. As checkpoint inhibition and tyrosine-kinase inhibitors have turn into cornerstones of most cancers remedy, bigger research and long-term observations are wanted to research the dangers and advantages throughout completely different sequences of remedy.
Dietary composition and proteomic evaluation of soft-shelled turtle (Pelodiscus sinensis) egg and identification of oligopeptides with alpha-glucosidase inhibitory exercise
This research aimed to discover dietary compositions and proteomics of soft-shelled turtle (SST) egg, in addition to establish potential antidiabetic oligopeptides with α-glucosidase inhibitory property. Outcomes revealed that SST egg is a promising supply of extremely nutritious proteins and minerals (54.64% and 5.81% of dry matter, respectively). Additional proteomic evaluation confirmed SST egg proteins contained not less than 9 protein households, comparable to transferrin/iron binding protein and immunoregulation-related protein. Hydrolysis by completely different enzymes, particularly papain, remarkably elevated α-glucosidase inhibitory exercise and scavenging exercise for ABTS, DPPH, hydroxyl and oxygen radicals of SST egg proteins.
Mouse Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
MBS8420623-1Kit |
MyBiosource |
1Kit |
EUR 755 |
Mouse Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
MBS8420623-5x1Kit |
MyBiosource |
5x1Kit |
EUR 3455 |
Plasminogen Activator Inhibitor Type 1, Recombinant, Mouse (PAI-1) |
MBS636215-05mg |
MyBiosource |
0.5mg |
EUR 1895 |
Plasminogen Activator Inhibitor Type 1, Recombinant, Mouse (PAI-1) |
MBS636215-5x05mg |
MyBiosource |
5x0.5mg |
EUR 8310 |
Plasminogen activator inhibitor 2 type A Antibody (HRP) |
abx109018-100l |
Abbexa |
100 µl |
EUR 162.5 |
Plasminogen activator inhibitor 2 type A Antibody (HRP) |
20-abx109018 |
Abbexa |
-
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-
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- 20 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
|
|
Plasminogen activator inhibitor 2 type A Antibody (FITC) |
abx107600-100g |
Abbexa |
100 µg |
EUR 362.5 |
Plasminogen activator inhibitor 2 type A Antibody (FITC) |
20-abx107600 |
Abbexa |
-
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-
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-
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-
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-
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|
- 20 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
|
|
Plasminogen activator inhibitor 2 type A Antibody (FITC) |
abx107600-20g |
Abbexa |
20 µg |
EUR 162.5 |
Plasminogen activator inhibitor 2 type A Antibody (FITC) |
abx107600-50g |
Abbexa |
50 µg |
EUR 250 |
Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
abx106186-100g |
Abbexa |
100 µg |
EUR 362.5 |
Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
20-abx106186 |
Abbexa |
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-
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|
- 20 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
|
|
Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
abx106186-20g |
Abbexa |
20 µg |
EUR 162.5 |
Plasminogen activator inhibitor 2 type A Antibody (Biotin) |
abx106186-50g |
Abbexa |
50 µg |
EUR 250 |
Plasminogen activator inhibitor type-1 (PAI-1): Human, Mouse monoclonal (Antibody) |
MBS398043-01mg |
MyBiosource |
0.1mg |
EUR 390 |
Plasminogen activator inhibitor type-1 (PAI-1): Human, Mouse monoclonal (Antibody) |
MBS398043-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1660 |
Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
1-CSB-EP021070RA |
Cusabio |
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- 10ug
- 50ug
- 100ug
- 200ug
- 500ug
- 1MG
|
|
Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in E.coli |
Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
1-CSB-YP021070RA |
Cusabio |
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- 10ug
- 50ug
- 100ug
- 200ug
- 500ug
- 1MG
|
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Description: Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) expressed in Yeast |
Mouse Hepatocyte Growth Factor Activator Inhibitor Type 1 (Kunitz-Type) ELISA Kit |
IMSHAI1KT |
Innovative research |
each |
EUR 702 |
|
Description: Mouse Hepatocyte Growth Factor Activator Inhibitor Type 1 (Kunitz-Type) ELISA Kit |
Mouse Hepatocyte Growth Factor Activator Inhibitor Type 1 (Kunitz-Type) ELISA Kit |
MBS8420622-1Kit |
MyBiosource |
1Kit |
EUR 755 |
Mouse Hepatocyte Growth Factor Activator Inhibitor Type 1 (Kunitz-Type) ELISA Kit |
MBS8420622-5x1Kit |
MyBiosource |
5x1Kit |
EUR 3455 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS951741-002mgEColi |
MyBiosource |
0.02mg(E-Coli) |
EUR 320 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS951741-002mgYeast |
MyBiosource |
0.02mg(Yeast) |
EUR 320 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS951741-01mgEColi |
MyBiosource |
0.1mg(E-Coli) |
EUR 520 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS951741-01mgYeast |
MyBiosource |
0.1mg(Yeast) |
EUR 515 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS951741-05mgYeast |
MyBiosource |
0.5mg(Yeast) |
EUR 1260 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9420660-002mg |
MyBiosource |
0.02mg |
EUR 380 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9420660-01mg |
MyBiosource |
0.1mg |
EUR 650 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9420660-1mg |
MyBiosource |
1mg |
EUR 2525 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9420660-5x1mg |
MyBiosource |
5x1mg |
EUR 11205 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9422489-002mg |
MyBiosource |
0.02mg |
EUR 380 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9422489-01mg |
MyBiosource |
0.1mg |
EUR 650 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9422489-05mg |
MyBiosource |
0.5mg |
EUR 1655 |
Recombinant Rat Plasminogen activator inhibitor 2 type A |
MBS9422489-5x05mg |
MyBiosource |
5x0.5mg |
EUR 7290 |
Mouse Anti Human Plasminogen Activator Inhibitor-1 |
MBS146983-0005mg |
MyBiosource |
0.005mg |
EUR 240 |
Mouse Anti Human Plasminogen Activator Inhibitor-1 |
MBS146983-002mg |
MyBiosource |
0.02mg |
EUR 310 |
Mouse Anti Human Plasminogen Activator Inhibitor-1 |
MBS146983-01mg |
MyBiosource |
0.1mg |
EUR 610 |
Mouse Anti Human Plasminogen Activator Inhibitor-1 |
MBS146983-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2405 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (AP) |
MBS6493734-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (AP) |
MBS6493734-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (PE) |
MBS6493744-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (PE) |
MBS6493744-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
Rat Plasminogen activator inhibitor 2 type A ELISA Kit |
MBS2887196-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 4080 |
Rat Plasminogen activator inhibitor 2 type A ELISA Kit |
MBS2887196-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 390 |
Rat Plasminogen activator inhibitor 2 type A ELISA Kit |
MBS2887196-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2220 |
Rat Plasminogen activator inhibitor 2 type A ELISA Kit |
MBS2887196-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 520 |
Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) Antibody |
20-abx142243 |
Abbexa |
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|
|
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody |
MBS1492996-005mg |
MyBiosource |
0.05mg |
EUR 190 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody |
MBS1492996-01mg |
MyBiosource |
0.1mg |
EUR 270 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody |
MBS1492996-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1205 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (AP) |
MBS6124759-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (AP) |
MBS6124759-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (PE) |
MBS6125927-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (PE) |
MBS6125927-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (APC) |
MBS6493735-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (APC) |
MBS6493735-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (Biotin) |
MBS6493736-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (Biotin) |
MBS6493736-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (FITC) |
MBS6493737-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (FITC) |
MBS6493737-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (HRP) |
MBS6493738-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (HRP) |
MBS6493738-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (APC) |
MBS6124992-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (APC) |
MBS6124992-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (HRP) |
MBS6125694-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (HRP) |
MBS6125694-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS609010-05mg |
MyBiosource |
0.5mg |
EUR 1195 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS609010-1mg |
MyBiosource |
1mg |
EUR 2145 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS609010-5x1mg |
MyBiosource |
5x1mg |
EUR 9515 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS631833-01mg |
MyBiosource |
0.1mg |
EUR 795 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS631833-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3430 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632094-1mg |
MyBiosource |
1mg |
EUR 1560 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632094-5x1mg |
MyBiosource |
5x1mg |
EUR 6875 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS632788-01mg |
MyBiosource |
0.1mg |
EUR 725 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS632788-5x01mg |
MyBiosource |
5x0.1mg |
EUR 3110 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632459-1mg |
MyBiosource |
1mg |
EUR 2115 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632459-5x1mg |
MyBiosource |
5x1mg |
EUR 9375 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632488-1mg |
MyBiosource |
1mg |
EUR 2115 |
Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1) |
MBS632488-5x1mg |
MyBiosource |
5x1mg |
EUR 9375 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS632491-1mg |
MyBiosource |
1mg |
EUR 2215 |
Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) |
MBS632491-5x1mg |
MyBiosource |
5x1mg |
EUR 9825 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 405) |
MBS6493739-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 405) |
MBS6493739-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 490) |
MBS6493740-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 490) |
MBS6493740-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 550) |
MBS6493741-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 550) |
MBS6493741-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 650) |
MBS6493742-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 650) |
MBS6493742-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 750) |
MBS6493743-01mL |
MyBiosource |
0.1mL |
EUR 1100 |
PAI-1 (Plasminogen Activator Inhibitor Type 1, SERPINE1, PAI, PAI1, PAI-1, PLANH1, Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I) (MaxLight 750) |
MBS6493743-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4810 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (FITC) |
MBS6125460-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (FITC) |
MBS6125460-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (Biotin) |
MBS6125226-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (Biotin) |
MBS6125226-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
ELISA Kit for Rat Plasminogen activator inhibitor 2 type A |
E2128r |
EIAab |
96T |
EUR 387.4 |
Plasminogen Activator Inhibitor Type 1, wild type, Rat (PAI-1) |
MBS634485-05mg |
MyBiosource |
0.5mg |
EUR 1665 |
Plasminogen Activator Inhibitor Type 1, wild type, Rat (PAI-1) |
MBS634485-5x05mg |
MyBiosource |
5x0.5mg |
EUR 7270 |
Recombinant Mouse Plasminogen Activator Inhibitor-2 |
MBS146819-0002mg |
MyBiosource |
0.002mg |
EUR 240 |
Recombinant Mouse Plasminogen Activator Inhibitor-2 |
MBS146819-001mg |
MyBiosource |
0.01mg |
EUR 310 |
Recombinant Mouse Plasminogen Activator Inhibitor-2 |
MBS146819-1mg |
MyBiosource |
1mg |
EUR 5345 |
Recombinant Mouse Plasminogen Activator Inhibitor-2 |
MBS146819-5x1mg |
MyBiosource |
5x1mg |
EUR 23725 |
Plasminogen Activator Inhibitor-2 Mouse Recombinant |
rAP-1489 |
Angio Proteomie |
Inquiry |
Ask for price |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, FITC |
MBS1498327-005mg |
MyBiosource |
0.05mg |
EUR 190 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, FITC |
MBS1498327-01mg |
MyBiosource |
0.1mg |
EUR 270 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, FITC |
MBS1498327-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1205 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (AP) |
MBS6493712-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (AP) |
MBS6493712-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (PE) |
MBS6493722-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (PE) |
MBS6493722-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type I (PAI-1) (AP) |
MBS6493723-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (AP) |
MBS6493723-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type I (PAI-1) (PE) |
MBS6493733-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (PE) |
MBS6493733-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (APC) |
MBS6493713-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (APC) |
MBS6493713-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (HRP) |
MBS6493716-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (HRP) |
MBS6493716-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type I (PAI-1) (APC) |
MBS6493724-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (APC) |
MBS6493724-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type I (PAI-1) (HRP) |
MBS6493727-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (HRP) |
MBS6493727-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1, wild type, Rabbit (PAI-1) |
MBS634607-05mg |
MyBiosource |
0.5mg |
EUR 1355 |
Plasminogen Activator Inhibitor Type 1, wild type, Rabbit (PAI-1) |
MBS634607-5x05mg |
MyBiosource |
5x0.5mg |
EUR 5865 |
Recombinant Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
CSB-EP021070RA |
Cusabio |
2162 mg |
Ask for price |
Recombinant Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
CSB-EP021070RA-20ug |
Cusabio |
20ug |
Ask for price |
|
Description: 1-416aa |
Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) |
AP70763 |
SAB |
1mg |
EUR 2826 |
|
Recombinant Rat Plasminogen activator inhibitor 2 type A(Serpinb2) |
AP72776 |
SAB |
each |
Ask for price |
|
Recombinant Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
CSB-YP021070RA |
Cusabio |
5988 mg |
Ask for price |
Recombinant Rat Plasminogen activator inhibitor 2 type A (Serpinb2) |
CSB-YP021070RA-20ug |
Cusabio |
20ug |
Ask for price |
|
Description: 1-416aa |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (FITC) |
MBS6493715-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (FITC) |
MBS6493715-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type I (PAI-1) (FITC) |
MBS6493726-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (FITC) |
MBS6493726-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1, wild type, Porcine (PAI-1) |
MBS634815-05mg |
MyBiosource |
0.5mg |
EUR 1565 |
Plasminogen Activator Inhibitor Type 1, wild type, Porcine (PAI-1) |
MBS634815-5x05mg |
MyBiosource |
5x0.5mg |
EUR 6820 |
Sheep anti-Human Plasminogen Activator Inhibitor Type 1 polyclonal antibody |
CABT-L494 |
Creative Diagnostics |
10 mg |
EUR 496.86 |
Description: Sheep |
Sheep anti-Human Plasminogen Activator Inhibitor Type 1 polyclonal antibody |
CABT-L495 |
Creative Diagnostics |
200ug |
EUR 525 |
Description: Sheep |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (Biotin) |
MBS6493714-01mL |
MyBiosource |
0.1mL |
EUR 635 |
Plasminogen Activator Inhibitor Type 1 (PAI-1) (Biotin) |
MBS6493714-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2700 |
Plasminogen Activator Inhibitor Type I (PAI-1) (Biotin) |
MBS6493725-01mL |
MyBiosource |
0.1mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type I (PAI-1) (Biotin) |
MBS6493725-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Mouse Plasminogen Activator Inhibitor 2 ELISA kit |
E03P0057-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 2 ELISA kit |
E03P0057-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 2 ELISA kit |
E03P0057-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Plasminogen Activator Inhibitor 2 ELISA kit |
E01A24356 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS020364-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS020364-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS020364-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS020364-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
IMSPAI2KT |
Innovative research |
each |
EUR 684 |
|
Description: Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS761904-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3900 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS761904-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 340 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS761904-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2045 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS761904-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 455 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS729945-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS729945-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS729945-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Mouse Plasminogen Activator Inhibitor 2 ELISA Kit |
MBS729945-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
Plasminogen Activator Inhibitor Type 1, wild type active, Murine (PAI-1) |
MBS634761-05mg |
MyBiosource |
0.5mg |
EUR 1540 |
Plasminogen Activator Inhibitor Type 1, wild type active, Murine (PAI-1) |
MBS634761-5x05mg |
MyBiosource |
5x0.5mg |
EUR 6715 |
Human Plasminogen Activator Inhibitor Type 1 ELISA Kit |
MBS3802851-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Human Plasminogen Activator Inhibitor Type 1 ELISA Kit |
MBS3802851-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Human Plasminogen Activator Inhibitor Type 1 ELISA Kit |
MBS3802851-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Human Plasminogen Activator Inhibitor Type 1 ELISA Kit |
MBS3802851-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 490) |
MBS6198965-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 490) |
MBS6198965-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 405) |
MBS6188290-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 405) |
MBS6188290-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 650) |
MBS6220315-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 650) |
MBS6220315-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 750) |
MBS6230990-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 750) |
MBS6230990-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 550) |
MBS6209640-01mL |
MyBiosource |
0.1(mL |
EUR 1090 |
Plasminogen Activator Inhibitor Type 1 (PAI1) (MaxLight 550) |
MBS6209640-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4750 |
Mouse Plasminogen Activator Inhibitor 2 (PAI2) Protein |
20-abx068563 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 10 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
|
|
Mouse Plasminogen Activator Inhibitor 2 (PAI2) Protein |
abx068563-20g |
Abbexa |
20 µg |
EUR 412.5 |
Mouse Plasminogen Activator Inhibitor 2 (PAI2) Protein |
abx068563-5g |
Abbexa |
5 µg |
EUR 225 |
Plasminogen Activator Inhibitor Type 1, latent wild type, Human (PAI-1) |
MBS634472-05mg |
MyBiosource |
0.5mg |
EUR 1520 |
Plasminogen Activator Inhibitor Type 1, latent wild type, Human (PAI-1) |
MBS634472-5x05mg |
MyBiosource |
5x0.5mg |
EUR 6630 |
Plasminogen Activator Inhibitor Type 1, wild type latent, Murine (PAI-1) |
MBS635253-05mg |
MyBiosource |
0.5mg |
EUR 1520 |
Plasminogen Activator Inhibitor Type 1, wild type latent, Murine (PAI-1) |
MBS635253-5x05mg |
MyBiosource |
5x0.5mg |
EUR 6630 |
Mouse Plasminogen Activator Inhibitor 2 (PAI-2) CLIA Kit |
abx197483-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Mouse PAI-2 (Plasminogen Activator Inhibitor 2) CLIA Kit |
MBS2531350-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2565 |
Mouse PAI-2 (Plasminogen Activator Inhibitor 2) CLIA Kit |
MBS2531350-96Tests |
MyBiosource |
96Tests |
EUR 560 |
Human Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
IHUHAI2KT |
Innovative research |
each |
EUR 702 |
|
Description: Human Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
Human Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
MBS8412755-1Kit |
MyBiosource |
1Kit |
EUR 755 |
Human Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) ELISA Kit |
MBS8412755-5x1Kit |
MyBiosource |
5x1Kit |
EUR 3455 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, HRP conjugated |
MBS1493777-005mg |
MyBiosource |
0.05mg |
EUR 190 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, HRP conjugated |
MBS1493777-01mg |
MyBiosource |
0.1mg |
EUR 270 |
Rabbit anti-rat Plasminogen activator inhibitor 2 type A polyclonal Antibody, HRP conjugated |
MBS1493777-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1205 |
Mouse PAI-2(Plasminogen Activator Inhibitor 2) ELISA Kit |
EM1263 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.234 ng/ml |
Mouse PAI-2(Plasminogen Activator Inhibitor 2) ELISA Kit |
EKF58516-48T |
Biomatik Corporation |
48T |
EUR 396.9 |
Mouse PAI-2(Plasminogen Activator Inhibitor 2) ELISA Kit |
EKF58516-5x96T |
Biomatik Corporation |
5x96T |
EUR 2693.25 |
Mouse PAI-2(Plasminogen Activator Inhibitor 2) ELISA Kit |
EKF58516-96T |
Biomatik Corporation |
96T |
EUR 567 |
Mouse PAI-2 (Plasminogen Activator Inhibitor 2) ELISA Kit |
MBS2502281-10x96Tests |
MyBiosource |
10x96Tests |
EUR 4060 |
Peptides from papain hydrolysate had been fractionated utilizing ultrafiltration adopted by reverse section chromatography, and 16 peptides had been recognized in probably the most lively fraction by LC-QTOF-MS/MS. Molecular docking revealed that 14 of those peptides might simply dock into the substrate-binding pocket and/or inhibitor binding websites of α-glucosidase with the docking rating beneath -150 kcal/mol, indicating their potential α-glucosidase inhibitory properties.
The 5 most considerable oligopeptides with potent interplay with α-glucosidase had been additional synthesized, and oligopeptides HNKPEVEVR, ARDASVLK and SGTLLHK strongly inhibited the exercise of α-glucosidase (IC50 of 56, 195 and 289 µmol/L, respectively). Subsequently, oligopeptides from enzymatic hydrolysate of SST egg protein exhibit potential antidiabetic exercise, making it a promising practical meals ingredient.