Species-Specific Urothelial Toxicity with an anti-HIV Non-Catalytic Site Integrase Inhibitor (NCINI) is Related to Unusual pH-Dependent Physicochemical Changes

August 22, 2021 Leave a comment
GS-9695 and GS-9822 are subsequent technology Non-Catalytic Website Integrase Inhibitors (NCINIs) with considerably improved efficiency towards HIV in contrast with earlier medication equivalent to BI-224436. Improvement stopped because of vacuolation of the bladder urothelium seen in cynomolgus monkey however not in rat; this lesion was absent in equal preclinical research with BI-224436 (examined in canine and rat).
Lesions had been unlikely to be attributable to focus on since NCINIs particularly goal viral integrase protein and no mammalian homologue is thought. Secondary pharmacology research, mitochondrial toxicity research, immunophenotyping and evaluation of proteins implicated in cell-cell interactions and/or bladder integrity (e-cadherin, pan-cytokeratin, uroplakins) failed to supply any believable rationalization for the species-specificity of the lesion.
Because it was characterised by irritation and disruption of urothelial morphology, we investigated physicochemical adjustments within the bladder of cynomolgus monkey (urinary pH 5.5-7.4) which may not happen within the bladder of rats (urinary pH 7.3-8.5). In measurements of floor exercise, GS-9822 confirmed an uncommon transition from a monolayer to a bilayer on the air/water interface with reducing pH, attributed to the sturdy affiliation between drug molecules in adjoining bilayer leaflets and anticipated to be extremely disruptive to the urothelium.
Structural evaluation of GS-9822 and GS-9695 confirmed zwitterionic traits over the vary of pH anticipated in cynomolgus monkey however not rat urine. This unique floor behaviour is unlikely with BI-224436 since it could transition from impartial to cationic (by no means zwitterionic) with reducing pH. These knowledge present helpful insights to information discovery and growth of NCINIs, associated compounds and zwitterions.

A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte damage in metabolic syndrome mannequin rats

Metabolic syndrome (MetS) is related to continual kidney illness and proteinuria. Beforehand, we reported {that a} artificial serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent illness fashions. The current examine evaluated the anti-hypertensive and anti-proteinuric results of CM in MetS mannequin rats (SHR/ND mcr-cp). Rats had been divided into regular salt-fed (NS), excessive salt-fed (HS), HS and CM-treated (CM), and HS and hydralazine-treated (Hyd) teams. Rats had been sacrificed after 4 weeks of remedy. Extreme hypertension and proteinuria had been noticed within the HS group.
Though CM and Hyd equally alleviated hypertension, CM suppressed proteinuria and glomerular sclerosis extra effectively than Hyd. The HS group revealed a lower in podocyte quantity and podocyte-specific molecules, along with a rise in glomerular apoptotic cells and apoptosis-related proteins within the kidney. These adjustments had been considerably attenuated by CM, however not by Hyd.
Moreover, CM ameliorated the apoptotic alerts in murine cultured podocytes stimulated with the excessive glucose and aldosterone medium. In conclusion, CM may exert renoprotective results in MetS mannequin rats, along with the inhibition of podocyte apoptosis. Our examine means that serine protease inhibition might turn into a brand new therapeutic technique towards MetS-related hypertension and renal accidents.

Efficacy and security of TAS-115, a novel oral multi-kinase inhibitor, in osteosarcoma: an enlargement cohort of a section I examine

Background osteosarcoma is a uncommon, main malignant bone tumour with restricted out there remedies for superior or recurrent illness, leading to a poor prognosis for sufferers. TAS-115 is a novel tyrosine kinase inhibitor beneath investigation in a section I examine in sufferers with strong tumours. We report knowledge of osteosarcoma sufferers within the enlargement cohort of this ongoing examine.
Sufferers and strategies an evaluation of this multicentre, open-label examine was carried out 6 months after the ultimate affected person was enrolled, and included sufferers aged ≥15 years, with unresectable or recurrent osteosarcoma, and who had refractory to straightforward remedy or for whom no customary remedy was out there. TAS-115 650 mg/day was orally administered in a 5 days on/2 days off schedule.
Species-Specific Urothelial Toxicity with an anti-HIV Non-Catalytic Site Integrase Inhibitor (NCINI) is Related to Unusual pH-Dependent Physicochemical ChangesOutcomes a complete of 20 sufferers with osteosarcoma had been enrolled. The most typical antagonistic drug reactions (ADRs) had been neutrophil depend decreased (75%), aspartate aminotransferase elevated (50%), and platelet depend decreased (50%); 85% of sufferers had grade ≥ Three ADRs. Lengthy-term illness management (>1 yr) with TAS-115 was achieved in three sufferers. One of the best general response was steady illness (50%); no affected person achieved an entire or partial response.
Median progression-free survival was Three months; 4-month and 12-month progression-free charges had been 42% and 31%, respectively. Conclusion the protection and tolerability of TAS-115 and long-term illness stability for sufferers with unresectable or recurrent osteosarcoma had been confirmed on this examine, suggesting that TAS-115 is a promising novel remedy for superior osteosarcoma sufferers. Trial registration quantity: JapicCTI-132333 (registered on November 8, 2013).

Inhibitory neurons within the superior colliculus mediate number of spatially-directed actions

Choice making is a cognitive course of that mediates behaviors essential for survival. Selecting spatial targets is an experimentally-tractable type of resolution making that will depend on the midbrain superior colliculus (SC). Whereas physiological and computational research have uncovered the practical topographic group of the SC, the position of particular SC cell varieties in spatial selection is unknown. Right here, we leveraged conduct, optogenetics, neural recordings and modeling to straight look at the contribution of GABAergic SC neurons to the number of opposing spatial targets.

Wnt Inhibitory Factor 1 (WIF1) Antibody
abx028141-400ul 400 ul
EUR 627.6

Wnt Inhibitory Factor 1 (WIF1) Antibody
abx028141-80l 80 µl
EUR 343.2

WNT Inhibitory Factor 1 (WIF1) Antibody
20-abx130317
  • EUR 577.20
  • EUR 159.60
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Wnt Inhibitory Factor 1 (WIF1) Antibody
20-abx334135
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Wnt Inhibitory Factor 1 (WIF1) Antibody
20-abx004124
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Wnt Inhibitory Factor 1 (WIF1) Antibody
abx011728-100ul 100 ul
EUR 493.2

Dog Wnt inhibitory factor 1 ELISA kit
E08W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Wnt inhibitory factor 1 ELISA kit
E08W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Wnt inhibitory factor 1 ELISA kit
E08W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Wnt inhibitory factor 1 ELISA kit
E02W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Wnt inhibitory factor 1 ELISA kit
E02W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Wnt inhibitory factor 1 ELISA kit
E02W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Wnt inhibitory factor 1 ELISA kit
E07W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Wnt inhibitory factor 1 ELISA kit
E07W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Wnt inhibitory factor 1 ELISA kit
E07W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Wnt inhibitory factor 1 ELISA kit
E06W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Wnt inhibitory factor 1 ELISA kit
E06W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Wnt inhibitory factor 1 ELISA kit
E06W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant WNT Inhibitory Factor 1 (WIF1)
4-RPL826Ra01
  • EUR 633.95
  • EUR 292.80
  • EUR 2047.30
  • EUR 762.43
  • EUR 1404.86
  • EUR 499.20
  • EUR 4938.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat WNT Inhibitory Factor 1 expressed in: E.coli

Mouse Wnt inhibitory factor 1 ELISA kit
E03W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Wnt inhibitory factor 1 ELISA kit
E03W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Wnt inhibitory factor 1 ELISA kit
E03W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Wnt inhibitory factor 1 ELISA kit
E01W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Wnt inhibitory factor 1 ELISA kit
E01W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Wnt inhibitory factor 1 ELISA kit
E01W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Human WNT Inhibitory Factor 1
7-06889 2µg Ask for price

Recombinant Human WNT Inhibitory Factor 1
7-06890 5µg Ask for price

Recombinant Human WNT Inhibitory Factor 1
7-06891 10µg Ask for price

Rat WNT Inhibitory Factor 1 (WIF1) Protein
20-abx168544
  • EUR 878.40
  • EUR 343.20
  • EUR 2749.20
  • EUR 1045.20
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Wnt Inhibitory Factor 1 (WIF-1) Antibody
20-abx142307
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Rabbit Wnt inhibitory factor 1 ELISA kit
E04W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Wnt inhibitory factor 1 ELISA kit
E04W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Wnt inhibitory factor 1 ELISA kit
E04W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Wnt inhibitory factor 1 ELISA kit
E09W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Wnt inhibitory factor 1 ELISA kit
E09W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Wnt inhibitory factor 1 ELISA kit
E09W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Wnt Inhibitory Factor 1 (WIF1) Antibody (HRP)
20-abx338323
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Wnt Inhibitory Factor 1 Recombinant Protein
91-363 0.05 mg
EUR 556.8
Description: Wnt Inhibitory Factor 1 (WIF1) is a secreted protein, which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis.WIF1 may be involved in mesoderm segmentation. WIF1 is a tumor suppressor, specifically in nonfunctioning pituitary tumors.

Human WNT Inhibitory Factor 1 (WIF1) Protein
20-abx655525
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Wnt Inhibitory Factor 1 (WIF1) Antibody (FITC)
20-abx338324
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat Wnt inhibitory factor 1 (Wif1) ELISA Kit
abx520194-96tests 96 tests
EUR 801.6

Rat Wif1/ Wnt inhibitory factor 1 ELISA Kit
E1035Ra 1 Kit
EUR 685.2

Rat WNT Inhibitory Factor 1(WIF1)ELISA Kit
QY-E10421 96T
EUR 433.2

Wnt Inhibitory Factor 1 (WIF1) Antibody (Biotin)
20-abx338325
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human WNT Inhibitory Factor 1 (WIF1) CLIA Kit
20-abx190372
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Human Wnt inhibitory factor 1
EK4563 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Wnt inhibitory factor 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1)CLIA Kit
SCL826Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1)CLIA Kit
SCL826Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1)CLIA Kit
SCL826Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1)CLIA Kit
SCL826Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) CLIA Kit
4-SCL826Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human WNT Inhibitory Factor 1 (WIF1)serum, plasma, tissue homogenates and other biological fluids

Human WNT Inhibitory Factor 1 (WIF1)ELISA Kit
201-12-2362 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Wnt inhibitory factor 1 (WIF1) ELISA Kit
abx574904-96tests 96 tests
EUR 801.6

Mouse Wnt inhibitory factor 1 (Wif1) ELISA Kit
abx520193-96tests 96 tests
EUR 801.6

Human Wnt inhibitory factor 1(WIF1) ELISA kit
CSB-EL026113HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Wnt inhibitory factor 1 (WIF1) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Wnt inhibitory factor 1(WIF1) ELISA kit
1-CSB-EL026113HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Wnt inhibitory factor 1(WIF1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Wnt inhibitory factor 1(WIF1) ELISA kit
CSB-EL026113MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Wnt inhibitory factor 1 (WIF1) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Wnt inhibitory factor 1(WIF1) ELISA kit
1-CSB-EL026113MO
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Wnt inhibitory factor 1(WIF1) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
DLR-WIF1-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human WNT Inhibitory Factor 1 (WIF1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
DLR-WIF1-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human WNT Inhibitory Factor 1 (WIF1) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
20-abx153500
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Guinea pig Wnt inhibitory factor 1 ELISA kit
E05W0018-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Wnt inhibitory factor 1 ELISA kit
E05W0018-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Wnt inhibitory factor 1 ELISA kit
E05W0018-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Wnt inhibitory factor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human WIF1(Wnt inhibitory factor 1) ELISA Kit
EH2253 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Wnt inhibitory factor 1, WIF1 ELISA KIT
ELI-07466h 96 Tests
EUR 988.8

Mouse Wnt inhibitory factor 1, Wif1 ELISA KIT
ELI-07468m 96 Tests
EUR 1038

Human WIF1/ Wnt inhibitory factor 1 ELISA Kit
E2681Hu 1 Kit
EUR 685.2

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
SEL826Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
SEL826Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
SEL826Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
SEL826Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human WNT Inhibitory Factor 1 (WIF1) in serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
4-SEL826Hu
  • EUR 6288.00
  • EUR 3322.80
  • EUR 831.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human WNT Inhibitory Factor 1 (WIF1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RD-WIF1-Hu-48Tests 48 Tests
EUR 675.6

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RD-WIF1-Hu-96Tests 96 Tests
EUR 939.6

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RDR-WIF1-Hu-48Tests 48 Tests
EUR 706.8

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RDR-WIF1-Hu-96Tests 96 Tests
EUR 984

Human WNT Inhibitory Factor 1 ELISA Kit (WIF1)
RK02518 96 Tests
EUR 625.2

Mouse WNT Inhibitory Factor 1(WIF1)ELISA Kit
QY-E21628 96T
EUR 495.6

Human WNT Inhibitory Factor 1(WIF1)ELISA Kit
QY-E04479 96T
EUR 433.2

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RDR-WIF1-Hu-48T 48T
EUR 518.18
Description: serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RDR-WIF1-Hu-96T 96T
EUR 740.25
Description: serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1)ELISA Kit
YLA3063HU-48T 48T
EUR 435

Human WNT Inhibitory Factor 1 (WIF1)ELISA Kit
YLA3063HU-96T 96T
EUR 562.5

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RD-WIF1-Hu-48T 48T
EUR 493.5
Description: serum, plasma, tissue homogenates and other biological fluids.

Human WNT Inhibitory Factor 1 (WIF1) ELISA Kit
RD-WIF1-Hu-96T 96T
EUR 705
Description: serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Wnt inhibitory factor 1 (WIF1)
KTE60033-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Wnt inhibitory factor 1 (WIF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Wnt inhibitory factor 1 (WIF1)
KTE60033-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Wnt inhibitory factor 1 (WIF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Wnt inhibitory factor 1 (WIF1)
KTE60033-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Wnt inhibitory factor 1 (WIF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human WIF1 (WNT Inhibitory Factor 1)
ELK6336 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of WNT Inhibitory Factor 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat)
4-PAL826Ra01
  • EUR 330.00
  • EUR 3549.60
  • EUR 872.40
  • EUR 420.00
  • EUR 271.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1)

Wif1 ELISA Kit| Rat Wnt inhibitory factor 1 ELISA Kit
EF019482 96 Tests
EUR 826.8

WIF1 WNT Inhibitory Factor 1 Mouse Recombinant Protein
PROTQ9WUA1 Regular: 10ug
EUR 380.4
Description: WIF1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 359 amino acids (29-379a.a.) and having a molecular mass of 39.4kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).;WIF1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

WIF1 WNT Inhibitory Factor 1 Human Recombinant Protein
PROTQ9Y5W5 Regular: 5ug
EUR 501.6
Description: WIF1 produced in Hi-5 cells is a single, glycosylated polypeptide chain containing 369 amino acids (29-379 a.a.) and having a molecular mass of 40.5 kDa, (48kDa on SDS-PAGE). ;WIF1 is fused to 16 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.

Wif1 ELISA Kit| Mouse Wnt inhibitory factor 1 ELISA Kit
EF016512 96 Tests
EUR 826.8

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), PE
4-PAL826Ra01-PE
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with PE.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), APC
4-PAL826Ra01-APC
  • EUR 465.60
  • EUR 4664.40
  • EUR 1278.00
  • EUR 601.20
  • EUR 284.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with APC.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), Cy3
4-PAL826Ra01-Cy3
  • EUR 571.20
  • EUR 6169.20
  • EUR 1654.80
  • EUR 751.20
  • EUR 330.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with Cy3.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), HRP
4-PAL826Ra01-HRP
  • EUR 423.60
  • EUR 4062.00
  • EUR 1128.00
  • EUR 541.20
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with HRP.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), FITC
4-PAL826Ra01-FITC
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with FITC.

Recombinant Human WIF-1/Wnt inhibitory factor 1 Protein
RP00844 10 μg
EUR 196.8

Ribunuclease Inhibitor / RNase Inhibitor
105-310 2000 u
EUR 91.2

Ribunuclease Inhibitor / RNase Inhibitor
105-350 10000 u
EUR 284.4

Recombinant Human Wnt Inhibitory Factor 1/WIF-1 (C-6His)
C396-10ug 10ug
EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 0.5% CHAPS, pH 4.0.

Recombinant Human Wnt Inhibitory Factor 1/WIF-1 (C-6His)
C396-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 0.5% CHAPS, pH 4.0.

Recombinant Human Wnt Inhibitory Factor 1/WIF-1 (C-6His)
C396-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 0.5% CHAPS, pH 4.0.

Recombinant Human Wnt Inhibitory Factor 1/WIF-1 (C-6His)
C396-50ug 50ug
EUR 327.6
Description: Lyophilized from a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 0.5% CHAPS, pH 4.0.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), APC-Cy7
4-PAL826Ra01-APC-Cy7
  • EUR 788.40
  • EUR 9184.80
  • EUR 2413.20
  • EUR 1058.40
  • EUR 426.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with APC-Cy7.

WNT Inhibitory Factor 1 (WIF1) Polyclonal Antibody (Rat), Biotinylated
4-PAL826Ra01-Biotin
  • EUR 411.60
  • EUR 3489.60
  • EUR 1006.80
  • EUR 510.00
  • EUR 278.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat WNT Inhibitory Factor 1 (WIF1). This antibody is labeled with Biotin.

MAPKII Kinase Inhibitor (Hsp25 Kinase Inhibitor)
SIH-120A 1 mg
EUR 214.8
Description: The substance MAPKII Kinase Inhibitor is a hsp25 kinase inhibitor. It is synthetically produced and has a purity of >95%. The pure substance is white solid which is soluble in DMSO or H20.

Antizyme Inhibitor 1 (Antizyme inhibitor 1) Antibody
abx230450-100ug 100 ug
EUR 577.2

Antizyme Inhibitor 1 (Antizyme Inhibitor 1) Antibody
20-abx111016
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Syk Inhibitor
1983-1 each
EUR 151.2

Syk Inhibitor
1983-5 each
EUR 339.6

PKR Inhibitor
C4439-10 10 mg
EUR 247.2
Description: IC50: 186-210 nMPKR Inhibitor is a double-stranded RNA-activated protein kinase (PKR) inhibitor. Initiation of protein synthesis is reported to be regulated by kinase-dependent phosphorylation reactions.

PKR Inhibitor
C4439-25 25 mg
EUR 477.6
Description: IC50: 186-210 nMPKR Inhibitor is a double-stranded RNA-activated protein kinase (PKR) inhibitor. Initiation of protein synthesis is reported to be regulated by kinase-dependent phosphorylation reactions.

PKR Inhibitor
C4439-5 5 mg
EUR 164.4
Description: IC50: 186-210 nMPKR Inhibitor is a double-stranded RNA-activated protein kinase (PKR) inhibitor. Initiation of protein synthesis is reported to be regulated by kinase-dependent phosphorylation reactions.

ITK inhibitor
A3509-10 10 mg
EUR 927.6
Description: Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways.

ITK inhibitor
A3509-50 50 mg
EUR 2448
Description: Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways.

Lck Inhibitor
A3539-1 1 mg
EUR 184.8
Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family.

Lck Inhibitor
A3539-5 5 mg
EUR 266.4
Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family.

MEK inhibitor
A3594-10 10 mg
EUR 895.2
Description: A potent MEK inhibitor, Antitumor agent.

MEK inhibitor
A3594-5 5 mg
EUR 656.4
Description: A potent MEK inhibitor, Antitumor agent.

MEK inhibitor
A3594-5.1 10 mM (in 1mL DMSO)
EUR 717.6
Description: A potent MEK inhibitor, Antitumor agent.

CBF? Inhibitor
C3398-10 10 mg
EUR 243.6
Description: CBF? inhibitor is a small molecule which binds to CBF? and inhibits its association with Runx1 [1].Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBF? component (a RUNX protein) and an enhancer of binding, CBF?.

CBF? Inhibitor
C3398-25 25 mg
EUR 471.6
Description: CBF? inhibitor is a small molecule which binds to CBF? and inhibits its association with Runx1 [1].Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBF? component (a RUNX protein) and an enhancer of binding, CBF?.
Though GABAergic SC neurons comprise a heterogeneous inhabitants with native and long-range projections, our outcomes display that GABAergic SC neurons don’t regionally suppress premotor output, suggesting that practical long-range inhibition as an alternative performs a dominant position in spatial selection. An attractor mannequin requiring solely intrinsic SC circuitry was adequate to account for our experimental observations. General, our examine elucidates the position of GABAergic SC neurons in spatial selection.

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