GS-9695 and GS-9822 are subsequent technology Non-Catalytic Website Integrase Inhibitors (NCINIs) with considerably improved efficiency towards HIV in contrast with earlier medication equivalent to BI-224436. Improvement stopped because of vacuolation of the bladder urothelium seen in cynomolgus monkey however not in rat; this lesion was absent in equal preclinical research with BI-224436 (examined in canine and rat).
Lesions had been unlikely to be attributable to focus on since NCINIs particularly goal viral integrase protein and no mammalian homologue is thought. Secondary pharmacology research, mitochondrial toxicity research, immunophenotyping and evaluation of proteins implicated in cell-cell interactions and/or bladder integrity (e-cadherin, pan-cytokeratin, uroplakins) failed to supply any believable rationalization for the species-specificity of the lesion.
Because it was characterised by irritation and disruption of urothelial morphology, we investigated physicochemical adjustments within the bladder of cynomolgus monkey (urinary pH 5.5-7.4) which may not happen within the bladder of rats (urinary pH 7.3-8.5). In measurements of floor exercise, GS-9822 confirmed an uncommon transition from a monolayer to a bilayer on the air/water interface with reducing pH, attributed to the sturdy affiliation between drug molecules in adjoining bilayer leaflets and anticipated to be extremely disruptive to the urothelium.
Structural evaluation of GS-9822 and GS-9695 confirmed zwitterionic traits over the vary of pH anticipated in cynomolgus monkey however not rat urine. This unique floor behaviour is unlikely with BI-224436 since it could transition from impartial to cationic (by no means zwitterionic) with reducing pH. These knowledge present helpful insights to information discovery and growth of NCINIs, associated compounds and zwitterions.
A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte damage in metabolic syndrome mannequin rats
Metabolic syndrome (MetS) is related to continual kidney illness and proteinuria. Beforehand, we reported {that a} artificial serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent illness fashions. The current examine evaluated the anti-hypertensive and anti-proteinuric results of CM in MetS mannequin rats (SHR/ND mcr-cp). Rats had been divided into regular salt-fed (NS), excessive salt-fed (HS), HS and CM-treated (CM), and HS and hydralazine-treated (Hyd) teams. Rats had been sacrificed after 4 weeks of remedy. Extreme hypertension and proteinuria had been noticed within the HS group.
Though CM and Hyd equally alleviated hypertension, CM suppressed proteinuria and glomerular sclerosis extra effectively than Hyd. The HS group revealed a lower in podocyte quantity and podocyte-specific molecules, along with a rise in glomerular apoptotic cells and apoptosis-related proteins within the kidney. These adjustments had been considerably attenuated by CM, however not by Hyd.
Moreover, CM ameliorated the apoptotic alerts in murine cultured podocytes stimulated with the excessive glucose and aldosterone medium. In conclusion, CM may exert renoprotective results in MetS mannequin rats, along with the inhibition of podocyte apoptosis. Our examine means that serine protease inhibition might turn into a brand new therapeutic technique towards MetS-related hypertension and renal accidents.
Efficacy and security of TAS-115, a novel oral multi-kinase inhibitor, in osteosarcoma: an enlargement cohort of a section I examine
Background osteosarcoma is a uncommon, main malignant bone tumour with restricted out there remedies for superior or recurrent illness, leading to a poor prognosis for sufferers. TAS-115 is a novel tyrosine kinase inhibitor beneath investigation in a section I examine in sufferers with strong tumours. We report knowledge of osteosarcoma sufferers within the enlargement cohort of this ongoing examine.
Sufferers and strategies an evaluation of this multicentre, open-label examine was carried out 6 months after the ultimate affected person was enrolled, and included sufferers aged ≥15 years, with unresectable or recurrent osteosarcoma, and who had refractory to straightforward remedy or for whom no customary remedy was out there. TAS-115 650 mg/day was orally administered in a 5 days on/2 days off schedule.
Outcomes a complete of 20 sufferers with osteosarcoma had been enrolled. The most typical antagonistic drug reactions (ADRs) had been neutrophil depend decreased (75%), aspartate aminotransferase elevated (50%), and platelet depend decreased (50%); 85% of sufferers had grade ≥ Three ADRs. Lengthy-term illness management (>1 yr) with TAS-115 was achieved in three sufferers. One of the best general response was steady illness (50%); no affected person achieved an entire or partial response.
Median progression-free survival was Three months; 4-month and 12-month progression-free charges had been 42% and 31%, respectively. Conclusion the protection and tolerability of TAS-115 and long-term illness stability for sufferers with unresectable or recurrent osteosarcoma had been confirmed on this examine, suggesting that TAS-115 is a promising novel remedy for superior osteosarcoma sufferers. Trial registration quantity: JapicCTI-132333 (registered on November 8, 2013).
Inhibitory neurons within the superior colliculus mediate number of spatially-directed actions
Choice making is a cognitive course of that mediates behaviors essential for survival. Selecting spatial targets is an experimentally-tractable type of resolution making that will depend on the midbrain superior colliculus (SC). Whereas physiological and computational research have uncovered the practical topographic group of the SC, the position of particular SC cell varieties in spatial selection is unknown. Right here, we leveraged conduct, optogenetics, neural recordings and modeling to straight look at the contribution of GABAergic SC neurons to the number of opposing spatial targets.
 ELISA Kit) Mouse WNT-11(WNT-11) ELISA Kit |
|
EM0018 |
FN Test |
96T |
EUR 524.1 |
- Detection range: 31.2-2000 pg/ml
- Uniprot ID: P48615
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml |
 Wnt 6 antibody |
|
20R-1649 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Wnt 6 antibody |
 Wnt 2 antibody |
|
20R-1650 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Wnt 2 antibody |
 Wnt 4 antibody |
|
20R-1651 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Wnt 4 antibody |
 Wnt agonist 1 |
|
B6059-10 |
ApexBio |
10 mg |
EUR 137 |
|
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation. |
Wnt agonist 1 |
|
B6059-200 |
ApexBio |
200 mg |
EUR 751 |
|
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation. |
Wnt agonist 1 |
|
B6059-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 108 |
|
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation. |
Wnt agonist 1 |
|
B6059-50 |
ApexBio |
50 mg |
EUR 357 |
|
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation. |
 L Wnt-5a |
|
P0011014 |
Addexbio |
One Frozen vial |
EUR 543 |
 WNT-1, human recombinant |
|
4754-10 |
Biovision |
|
EUR 283 |
WNT-1, human recombinant |
|
4754-1000 |
Biovision |
|
EUR 5705 |
WNT-1, human recombinant |
|
4754-50 |
Biovision |
|
EUR 729 |
 Wnt 6 Blocking Peptide |
|
33R-10508 |
Fitzgerald |
50 ug |
EUR 349 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 6 antibody, catalog no. 20R-1649 |
 Wnt 2 Blocking Peptide |
|
33R-10509 |
Fitzgerald |
50 ug |
EUR 349 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 2 antibody, catalog no. 20R-1650 |
 Wnt 4 Blocking Peptide |
|
33R-10510 |
Fitzgerald |
50 ug |
EUR 349 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 4 antibody, catalog no. 20R-1651 |
 Wnt-6 Blocking Peptide |
|
3570BP-50 |
Biovision |
|
EUR 153 |
 Wnt-1 Blocking Peptide |
|
3571BP-50 |
Biovision |
|
EUR 153 |
 Wnt-2 Blocking Peptide |
|
3572RBP-50 |
Biovision |
|
EUR 153 |
 Wnt-4 Blocking Peptide |
|
3574BP-50 |
Biovision |
|
EUR 153 |
 Wnt-1 Polyclonal Antibody |
|
41535-100ul |
SAB |
100ul |
EUR 252 |
Wnt-1 Polyclonal Antibody |
|
41535-50ul |
SAB |
50ul |
EUR 187 |
 Polyclonal Wnt-6 Antibody |
|
APR00134G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-6 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Wnt-1 Antibody |
|
APR00135G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-1 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Wnt-2 Antibody |
|
APR00136G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-2 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Wnt-4 Antibody |
|
APR00137G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-4 . This antibody is tested and proven to work in the following applications: |
Polyclonal Wnt-1 Antibody |
|
APR00320G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-1 . This antibody is tested and proven to work in the following applications: |
Polyclonal Wnt-2 Antibody |
|
APR00346G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-2 . This antibody is tested and proven to work in the following applications: |
 Wnt-2, human recombinant |
|
7599-10 |
Biovision |
|
EUR 387 |
Wnt-2, human recombinant |
|
7599-1000 |
Biovision |
|
EUR 7988 |
Wnt-2, human recombinant |
|
7599-50 |
Biovision |
|
EUR 1186 |
 EZSolution? Wnt Antagonist, C59 |
|
9493-1 |
Biovision |
|
EUR 137 |
 Protein Wnt-3a Antibody |
|
20-abx110152 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Protein Wnt-3a Antibody |
|
20-abx137444 |
Abbexa |
-
EUR 704.00
-
EUR 328.00
-
EUR 230.00
|
|
- Shipped within 5-10 working days.
|
Wnt-1 Polyclonal Antibody |
|
ABP52707-003ml |
Abbkine |
0.03ml |
EUR 158 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350 |
Wnt-1 Polyclonal Antibody |
|
ABP52707-01ml |
Abbkine |
0.1ml |
EUR 289 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350 |
Wnt-1 Polyclonal Antibody |
|
ABP52707-02ml |
Abbkine |
0.2ml |
EUR 414 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350 |
 Wnt-16 Polyclonal Antibody |
|
ABP52837-003ml |
Abbkine |
0.03ml |
EUR 158 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Wnt-16
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16 |
Wnt-16 Polyclonal Antibody |
|
ABP52837-01ml |
Abbkine |
0.1ml |
EUR 289 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Wnt-16
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16 |
Wnt-16 Polyclonal Antibody |
|
ABP52837-02ml |
Abbkine |
0.2ml |
EUR 414 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Wnt-16
- Applications tips:
|
|
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16 |
Wnt-1 Polyclonal Antibody |
|
ES3706-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Wnt-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Wnt-1 Polyclonal Antibody |
|
ES3706-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Wnt-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Wnt-16 Polyclonal Antibody |
|
ES3836-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Wnt-16 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Wnt-16 Polyclonal Antibody |
|
ES3836-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Wnt-16 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
 WNT-3a, Human Recombinant |
|
P1194-100 |
Biovision |
|
EUR 615 |
WNT-3a, Human Recombinant |
|
P1194-20 |
Biovision |
|
EUR 196 |
 WNT-7a, Human Recombinant |
|
P1195-100 |
Biovision |
|
EUR 588 |
WNT-7a, Human Recombinant |
|
P1195-20 |
Biovision |
|
EUR 185 |
 Wnt-3a GMP, CF |
|
PR15121CF |
Neuromics |
10 ug |
EUR 649 |
 L Wnt-3A cells |
|
S0011001 |
Addexbio |
One Frozen vial |
EUR 455 |
 Anti-Wnt-1 antibody |
|
STJ96272 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Wnt-1. |
 Anti-Wnt-16 antibody |
|
STJ96471 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Wnt-16. |
Anti-Wnt-1 antibody |
|
STJ98451 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Wnt-1. |
 Anti-Wnt-10b antibody |
|
STJ98452 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Wnt-10b. |
 Anti-Wnt-5a antibody |
|
STJ98453 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Wnt-5a. |
Anti-Wnt-5a antibody |
|
STJ98454 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to Wnt-5a. |
 Protein Wnt-3a Polyclonal Antibody |
|
42596-100ul |
SAB |
100ul |
EUR 333 |
) Human Protein Wnt-2 (WNT2) |
|
1-CSB-EP026133HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 41.6 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-2(WNT2) expressed in E.coli |
) Human Protein Wnt-3a (WNT3A) |
|
1-CSB-EP026136HU |
Cusabio |
-
EUR 437.00
-
EUR 238.00
-
EUR 1544.00
-
EUR 653.00
-
EUR 1029.00
-
EUR 296.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 43.5 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-3a(WNT3A) expressed in E.coli |
) Mouse Protein Wnt-3a (Wnt3a) |
|
1-CSB-EP026136MO |
Cusabio |
-
EUR 437.00
-
EUR 238.00
-
EUR 1544.00
-
EUR 653.00
-
EUR 1029.00
-
EUR 296.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 40.9 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Mouse Protein Wnt-3a(Wnt3a) expressed in E.coli |
) Human Protein Wnt-4 (WNT4) |
|
1-CSB-EP026137HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 52.7 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-4(WNT4) expressed in E.coli |
 Human Protein Wnt-5a（WNT5A） |
|
1-CSB-EP026138HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 39.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-5a（WNT5A） expressed in E.coli |
) Human Protein Wnt-5a (WNT5A) |
|
1-CSB-EP026138HUa2 |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 51.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-5a(WNT5A) expressed in E.coli |
Human Protein Wnt-5a (WNT5A) |
|
1-CSB-EP026138HUb1 |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 40.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-5a(WNT5A) expressed in E.coli |
Human Protein Wnt-5a（WNT5A） |
|
1-CSB-EP026138HUb3 |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 55.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-5a（WNT5A） expressed in E.coli |
) Human Protein Wnt-7b (Wnt7b) |
|
1-CSB-EP026142HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 56.3 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-7b(Wnt7b) expressed in E.coli |
) Mouse Protein Wnt-7b (Wnt7b) |
|
1-CSB-EP026142MO |
Cusabio |
-
EUR 437.00
-
EUR 238.00
-
EUR 1544.00
-
EUR 653.00
-
EUR 1029.00
-
EUR 296.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 56.3 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Mouse Protein Wnt-7b(Wnt7b) expressed in E.coli |
) Mouse Protein Wnt-8b (Wnt8b) |
|
1-CSB-EP895748MO |
Cusabio |
-
EUR 611.00
-
EUR 309.00
-
EUR 1827.00
-
EUR 939.00
-
EUR 1218.00
-
EUR 397.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 56.2 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Mouse Protein Wnt-8b(Wnt8b) expressed in E.coli |
Human Protein Wnt-3a (WNT3A) |
|
1-CSB-RP155494h |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 41.3 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-3a(WNT3A),partial expressed in E.coli |
) Human Protein Wnt-10a (WNT10A) |
|
1-CSB-YP884424HU |
Cusabio |
-
EUR 430.00
-
EUR 234.00
-
EUR 1508.00
-
EUR 642.00
-
EUR 1009.00
-
EUR 291.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 44.4 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-10a(WNT10A) expressed in Yeast |
Human Protein Wnt-2 (WNT2) |
|
1-CSB-YP026133HU |
Cusabio |
-
EUR 430.00
-
EUR 234.00
-
EUR 1508.00
-
EUR 642.00
-
EUR 1009.00
-
EUR 291.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 39.6 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-2(WNT2) expressed in Yeast |
Human Protein Wnt-5a (WNT5A) |
|
1-CSB-YP026138HU |
Cusabio |
-
EUR 430.00
-
EUR 234.00
-
EUR 1508.00
-
EUR 642.00
-
EUR 1009.00
-
EUR 291.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 37.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-5a(WNT5A) expressed in Yeast |
) Human Protein Wnt-2b (WNT2B) |
|
1-CSB-YP856613HU |
Cusabio |
-
EUR 586.00
-
EUR 299.00
-
EUR 2172.00
-
EUR 900.00
-
EUR 1442.00
-
EUR 382.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
- MW: 45.8 kDa
- Buffer composition: Tris-based buffer with 50% glycerol.
|
|
Description: Recombinant Human Protein Wnt-2b(WNT2B) expressed in Yeast |
 Antibody) Protein Wnt-7b (WNT7B) Antibody |
|
20-abx007049 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-4 (WNT4) Antibody |
|
20-abx007069 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-1 (WNT1) Antibody |
|
20-abx008571 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-10b (WNT10B) Antibody |
|
abx016022-100ul |
Abbexa |
100 ul |
EUR 411 |
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-5a (WNT5A) Antibody |
|
abx016063-100ul |
Abbexa |
100 ul |
EUR 411 |
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-7a (WNT7A) Antibody |
|
20-abx004155 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
 Antibody) Protein Wnt-2 (WNT2) Antibody |
|
20-abx004501 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
- Shipped within 5-10 working days.
|
Though GABAergic SC neurons comprise a heterogeneous inhabitants with native and long-range projections, our outcomes display that GABAergic SC neurons don’t regionally suppress premotor output, suggesting that practical long-range inhibition as an alternative performs a dominant position in spatial selection. An attractor mannequin requiring solely intrinsic SC circuitry was adequate to account for our experimental observations. General, our examine elucidates the position of GABAergic SC neurons in spatial selection.
-Wnt-10a Plasmid)