Species-Specific Urothelial Toxicity with an anti-HIV Non-Catalytic Site Integrase Inhibitor (NCINI) is Related to Unusual pH-Dependent Physicochemical Changes

Choice making is a cognitive course of that mediates behaviors essential for survival. Selecting spatial targets is an experimentally-tractable type of resolution making that will depend on the midbrain superior colliculus (SC). Whereas physiological and computational research have uncovered the practical topographic group of the SC, the position of particular SC cell varieties in spatial selection is unknown. Right here, we leveraged conduct, optogenetics, neural recordings and modeling to straight look at the contribution of GABAergic SC neurons to the number of opposing spatial targets.

Wnt agonist 1
B6059-200	ApexBio	200 mg	EUR 751
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt agonist 1
B6059-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 108
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt agonist 1
B6059-50	ApexBio	50 mg	EUR 357
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt-6 Antibody
3570-100	Biovision		EUR 316

Wnt-6 Antibody
3570-30T	Biovision		EUR 146

Wnt-1 Antibody
3571-100	Biovision		EUR 316

Wnt-1 Antibody
3571-30T	Biovision		EUR 146

Wnt-2 Antibody
3572R-100	Biovision		EUR 354

Wnt-2 Antibody
3572R-30T	Biovision		EUR 146

Wnt-4 Antibody
3574R-100	Biovision		EUR 316

Wnt-4 Antibody
3574R-30T	Biovision		EUR 146

Wnt-1 Antibody
5754-100	Biovision		EUR 316

Wnt-1 Antibody
5754-30T	Biovision		EUR 146

Wnt-2 Antibody
6671-100	Biovision		EUR 338

Wnt-2 Antibody
6671-30T	Biovision		EUR 146

Wnt Antagonist, C59
2063-1	Biovision		EUR 137

Wnt Antagonist, C59
2063-5	Biovision		EUR 359

Wnt 6 antibody
20R-1649	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Wnt 6 antibody

Wnt 2 antibody
20R-1650	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Wnt 2 antibody

Wnt 4 antibody
20R-1651	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Wnt 4 antibody

WNT-11 ELISA Kit| Mouse WNT-11 ELISA Kit
EF012834	Lifescience Market	96 Tests	EUR 689

Wnt-1 Polyclonal Antibody
ES3706-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Wnt-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Wnt-16 Polyclonal Antibody
ES3836-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Wnt-16 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Wnt-1 Polyclonal Antibody
ES3706-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Wnt-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Wnt-16 Polyclonal Antibody
ES3836-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Wnt-16 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Protein Wnt-3a Antibody
20-abx137444	Abbexa	EUR 704.00 EUR 328.00 EUR 230.00	100 ug 20 ug 5 ug

Wnt-1 Polyclonal Antibody
ABP52707-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350

Wnt-1 Polyclonal Antibody
ABP52707-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350

Wnt-1 Polyclonal Antibody
ABP52707-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Wnt-1 from Human, Mouse. This Wnt-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Wnt-1 at AA range: 270-350

Wnt-16 Polyclonal Antibody
ABP52837-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16

Wnt-16 Polyclonal Antibody
ABP52837-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16

Wnt-16 Polyclonal Antibody
ABP52837-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Wnt-16 from Human, Mouse, Rat. This Wnt-16 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Wnt-16

Protein Wnt-3a Antibody
20-abx110152	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Anti-Wnt-1 antibody
STJ98451	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Wnt-1.

Anti-Wnt-10b antibody
STJ98452	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Wnt-10b.

Anti-Wnt-5a antibody
STJ98453	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Wnt-5a.

Anti-Wnt-5a antibody
STJ98454	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Wnt-5a.

Anti-Wnt-1 antibody
STJ96272	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Wnt-1.

Anti-Wnt-16 antibody
STJ96471	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Wnt-16.

Wnt-1 Polyclonal Antibody
41535-100ul	SAB	100ul	EUR 252

Wnt-1 Polyclonal Antibody
41535-50ul	SAB	50ul	EUR 187

L Wnt-3A cells
S0011001	Addexbio	One Frozen vial	EUR 455

Polyclonal Wnt-6 Antibody
APR00134G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-6 . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-1 Antibody
APR00135G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-1 . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-2 Antibody
APR00136G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-2 . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-4 Antibody
APR00137G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-4 . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-1 Antibody
APR00320G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-1 . This antibody is tested and proven to work in the following applications:

Polyclonal Wnt-2 Antibody
APR00346G	Leading Biology	0.1ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-2 . This antibody is tested and proven to work in the following applications:

Wnt-3a GMP, CF
PR15121CF	Neuromics	10 ug	EUR 649

Wnt-6 Blocking Peptide
3570BP-50	Biovision		EUR 153

Wnt-1 Blocking Peptide
3571BP-50	Biovision		EUR 153

Wnt-2 Blocking Peptide
3572RBP-50	Biovision		EUR 153

Wnt-4 Blocking Peptide
3574BP-50	Biovision		EUR 153

WNT-1, human recombinant
4754-10	Biovision		EUR 283

WNT-1, human recombinant
4754-1000	Biovision		EUR 5705

WNT-1, human recombinant
4754-50	Biovision		EUR 729

Wnt-2, human recombinant
7599-10	Biovision		EUR 387

Wnt-2, human recombinant
7599-1000	Biovision		EUR 7988

Wnt-2, human recombinant
7599-50	Biovision		EUR 1186

EZSolution? Wnt Antagonist, C59
9493-1	Biovision		EUR 137

WNT-3a, Human Recombinant
P1194-100	Biovision		EUR 615

WNT-3a, Human Recombinant
P1194-20	Biovision		EUR 196

WNT-7a, Human Recombinant
P1195-100	Biovision		EUR 588

WNT-7a, Human Recombinant
P1195-20	Biovision		EUR 185

pcDNA3.1(+)-Wnt-10a Plasmid
PVTB00127-2a	Lifescience Market	2 ug	EUR 356

Wnt 6 Blocking Peptide
33R-10508	Fitzgerald	50 ug	EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 6 antibody, catalog no. 20R-1649

Wnt 2 Blocking Peptide
33R-10509	Fitzgerald	50 ug	EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 2 antibody, catalog no. 20R-1650

Wnt 4 Blocking Peptide
33R-10510	Fitzgerald	50 ug	EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wnt 4 antibody, catalog no. 20R-1651

Wnt-1 Recombinant Protein
40-216-0002mg	ProSci	0.002 mg	EUR 259.25
Description: Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

Wnt-1 Recombinant Protein
40-216-001mg	ProSci	0.01 mg	EUR 364.25
Description: Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

WNT-7A Recombinant Protein
40-577-0003mg	ProSci	0.003 mg	EUR 259.25
Description: Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.

WNT-7A Recombinant Protein
40-577-0015mg	ProSci	0.015 mg	EUR 364.25
Description: Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.

Wnt-9b Recombinant Protein
40-653	ProSci	5 ug	EUR 259.25
Description: Formerly known as Wnt-15 or Wnt-14b, Wnt-9b is a secreted glycoprotein belonging to the Wnt family of signaling proteins that are critically involved in maintaining the integrity of both embryonic and adult tissues. Wnt-9b is primarily expressed in adult kidneys and during late embryogenesis, and shares with other Wnt family members the same highly conserved lipid-modified, cysteine-rich domain essential for cell signaling. As is true for most Wnt family members, Wnt-9b functions through the biochemical process known as the canonical Wnt pathway. In this process, Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, and ultimately results in the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote the expression of numerous genes. In this manner, Wnt signaling induces and maintains transformed phenotype, and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. While increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers, lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Altered Wnt-9b expression has been shown to result in the underdevelopment of the kidneys, and incomplete lip and cleft fusion in mice. Recombinant Human Wnt-9b is a monomeric glycoprotein containing 335 amino acid residues and has a calculated molecular weight of 36.9 kDa. Due to glycosylation, Recombinant Human Wnt-9b migrates at an apparent molecular weight of approximately 49-54 kDa by SDS-PAGE analysis under non-reducing conditions.

WNT-3A Recombinant Protein
40-700	ProSci	2 ug	EUR 259.25
Description: Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS). Wnt-3a signaling is essential for various morphogenetic events, including embryonic patterning, cell determination, cell proliferation, CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid-modified, cysteine-rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway, Wnt family members bind to and activate, seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant Murine Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues. Due to glycosylation, the Murine Wnt-3a migrates at an apparent molecular weight of approximately 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions.

Protein Wnt-10a (WNT10A) Antibody
20-abx301908	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Protein Wnt-4 (WNT4) Antibody
20-abx302751	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Recombinant Human WNT-1 Protein
PROTP04628	BosterBio	10ug	EUR 317
Description: Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

Recombinant Human WNT-7A Protein
PROTO00755-1	BosterBio	15ug	EUR 317
Description: Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions

Protein Wnt-2 (WNT2) Antibody
abx122394-100ug	Abbexa	100 ug	EUR 391

Protein Wnt-7b (WNT7B) Antibody
abx122911-100ug	Abbexa	100 ug	EUR 391

Protein Wnt-4 (WNT4) Antibody
20-abx116674	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Protein Wnt-7a (WNT7A) Antibody
20-abx116675	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Protein Wnt-3a (WNT3A) Antibody
abx117009-100ug	Abbexa	100 ug	EUR 467

Protein Wnt-5a (Wnt5a) Antibody
abx117221-100ug	Abbexa	100 ug	EUR 467

Protein Wnt-3a (WNT3A) Antibody
20-abx136135	Abbexa	EUR 495.00 EUR 704.00 EUR 356.00	100 ul 200 ul 50 ul

Protein Wnt-5a (Wnt5a) Antibody
20-abx123422	Abbexa	EUR 592.00 EUR 857.00 EUR 411.00	100 ul 200 ul 50 ul

Protein Wnt-6 (WNT6) Antibody
20-abx124423	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Protein Wnt-3a Antibody (Biotin)
20-abx105841	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Protein Wnt-3a Antibody (FITC)
20-abx107257	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Protein Wnt-3a Antibody (HRP)
20-abx108677	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Protein Wnt-4 (WNT4) Antibody
abx036970-100ug	Abbexa	100 ug	EUR 391

Protein Wnt-5a (WNT5A) Antibody
abx012361-100ul	Abbexa	100 ul	EUR 411

Though GABAergic SC neurons comprise a heterogeneous inhabitants with native and long-range projections, our outcomes display that GABAergic SC neurons don’t regionally suppress premotor output, suggesting that practical long-range inhibition as an alternative performs a dominant position in spatial selection. An attractor mannequin requiring solely intrinsic SC circuitry was adequate to account for our experimental observations. General, our examine elucidates the position of GABAergic SC neurons in spatial selection.